Modulation of hypercholesterolemia-induced oxidative/nitrative stress in the heart

Csaba Csonka, Márta Sárközy, Márton Pipicz, László Dux, Tamás Csont

Research output: Contribution to journalReview article

40 Citations (Scopus)


Hypercholesterolemia is a frequent metabolic disorder associated with increased risk for cardiovascular morbidity and mortality. In addition to its well-known proatherogenic effect, hypercholesterolemia may exert direct effects on the myocardium resulting in contractile dysfunction, aggravated ischemia/reperfusion injury, and diminished stress adaptation. Both preclinical and clinical studies suggested that elevated oxidative and/or nitrative stress plays a key role in cardiac complications induced by hypercholesterolemia. Therefore, modulation of hypercholesterolemia-induced myocardial oxidative/nitrative stress is a feasible approach to prevent or treat deleterious cardiac consequences. In this review, we discuss the effects of various pharmaceuticals, nutraceuticals, some novel potential pharmacological approaches, and physical exercise on hypercholesterolemia-induced oxidative/nitrative stress and subsequent cardiac dysfunction as well as impaired ischemic stress adaptation of the heart in hypercholesterolemia.

Original languageEnglish
Article number3863726
JournalOxidative medicine and cellular longevity
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

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