Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death

G. Szabó, Thilo Hackert, Christian Sebening, Christian Friedrich Vahl, Siegfried Hagl

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background. Brain death results in a rapid decline in left ventricular function, which has clinical relevance for organ transplantation. The aim of the present study was to investigate coronary perfusion changes during brain death and their role in cardiac dysfunction. Methods. In an in situ isolated canine heart model, brain death was induced by inflation of a subdural balloon catheter. The heart was perfused separately with the animal's own blood by a pressure-controlled roller pump that was coupled to the measured aortic pressure. Myocardial contractility was estimated by the slope of the end-systolic pressure-volume relation. Results. Induction of brain death resulted in a transient hyperdynamic response, followed by a significant decrease in systemic vascular resistance, coronary blood flow, and the end- systolic pressure-volume relation (p <0.05). However, if coronary perfusion pressure was decoupled from aortic pressure and elevated to pre-brain death levels, coronary blood flow and the end-systolic pressure-volume relation were also restored to baseline levels. Conclusion. Severe impairment of coronary blood flow may contribute to decreased contractility after brain death that can be reversed by modulation of coronary perfusion pressure.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalAnnals of Thoracic Surgery
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 1999

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Brain Death
Perfusion
Pressure
Blood Pressure
Arterial Pressure
Economic Inflation
Organ Transplantation
Left Ventricular Function
Vascular Resistance
Canidae
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. / Szabó, G.; Hackert, Thilo; Sebening, Christian; Vahl, Christian Friedrich; Hagl, Siegfried.

In: Annals of Thoracic Surgery, Vol. 67, No. 1, 01.1999, p. 18-26.

Research output: Contribution to journalArticle

Szabó, G. ; Hackert, Thilo ; Sebening, Christian ; Vahl, Christian Friedrich ; Hagl, Siegfried. / Modulation of coronary perfusion pressure can reverse cardiac dysfunction after brain death. In: Annals of Thoracic Surgery. 1999 ; Vol. 67, No. 1. pp. 18-26.
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