Modulation of catecholamine responsiveness and β-adrenergic receptor/adenylyl cyclase pathway during cardiac allograft rejection

G. Szabó, Susanne Bährle, Martin Braun, Nicole Stumpf, Christian F. Vahl, Siegfried Hagl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. This study investigated the changes of catecholamine responsiveness and β-adrenergic receptor/adenylyl cyclase pathway during acute cardiac transplant rejection. Methods. Isogeneic Lewis to Lewis and allogeneic Dark Agouti (DA) to Lewis rat cardiac transplants were studied 3 and 5 days after heterotopic intraabdominal transplantation (n=6/group). Myocardial blood flow (MBF), left ventricular systolic pressure (LVSP), maximum pressure development (+dP/dt), and end-diastolic pressure (LVEDP) were measured using an intraventricular balloon. Contractile response to dobutamine (5 μg/kg/min) was also assessed. In separate groups β-adrenergic receptor density and adenylyl cyclase activity were measured in the grafts, in the recipients' native hearts and in native hearts of sham-operated controls. Results. During mild to moderate rejection cardiac function indices remained unchanged, although MBF and contractile response to dobutamine decreased significantly (P

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalTransplantation
Volume73
Issue number4
Publication statusPublished - Feb 27 2002

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Dobutamine
Adenylyl Cyclases
Adrenergic Receptors
Catecholamines
Allografts
Heterotopic Transplantation
Blood Pressure
Transplants
Graft Rejection
Ventricular Pressure
Pressure
Dasyproctidae

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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Modulation of catecholamine responsiveness and β-adrenergic receptor/adenylyl cyclase pathway during cardiac allograft rejection. / Szabó, G.; Bährle, Susanne; Braun, Martin; Stumpf, Nicole; Vahl, Christian F.; Hagl, Siegfried.

In: Transplantation, Vol. 73, No. 4, 27.02.2002, p. 535-540.

Research output: Contribution to journalArticle

Szabó, G. ; Bährle, Susanne ; Braun, Martin ; Stumpf, Nicole ; Vahl, Christian F. ; Hagl, Siegfried. / Modulation of catecholamine responsiveness and β-adrenergic receptor/adenylyl cyclase pathway during cardiac allograft rejection. In: Transplantation. 2002 ; Vol. 73, No. 4. pp. 535-540.
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