Modulation of active avoidance behavior of rats by ICV administration of CGRP antiserum

A. Kovács, G. Telegdy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of ICV administration of CGRP antiserum on active avoidance behavior were studied in rats. CGRP antiserum dilutions of 1:5, 1:10, 1:20, and 1:40 facilitated the extinction of active avoidance responses in a platform-jumping situation in the 3- and 6-h tests. In the 24-h test, only the CGRP antiserum dilution of 1:5 was effective. The present findings suggest that the endogenous CGRP of the brain may be a physiological modulator in extinction processes of active avoidance behavior.

Original languageEnglish
Pages (from-to)893-895
Number of pages3
JournalPeptides
Volume15
Issue number5
DOIs
Publication statusPublished - 1994

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Keywords

  • Active avoidance behavior
  • Antiserum
  • Calcitonin gene-related peptide
  • ICV administration
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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