Modulation by thyroid hormones of the development of external plexiform layer in the rat olfactory bulb

Z. Hoyk, T. Szilagyi, N. Halasz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Width of the external plexiform layer in olfactory bulbs and mean area of mitral and granule cell dendritic and glial processes were measured of normal, hypo- and hyperthyroid rat pups at the age of 24 days. Hypothyroidism was induced by treating the rats with a reversible goitrogen 6-n-propyl-2- thiouracil dissolved in their drinking water, while the hyperthyroid group was given water containing thyroxine. The 6-n-propyl-2-thiouracil treatment was begun on gestational day 18 and on the day of birth. Thyroxine treatment started on the day of birth. Both treatments were continued till the day of sacrifice. A significant decrease in the width of the external plexiform layer of the olfactory bulb in the prenatally 6-n-propyl-2-thiouracil treated group and a significant increase in the width of the external plexiform layer of the hyperthyroid group was shown by the Student's paired t-test. The areas of neuronal and glial processes were measured at electron microscopic level by using an IBAS image analysing system. A significant decrease was found by the Kruskal-Wallis test and Dunn's range test in the mean area of (1) mitral cell dendrites in the prenatal 6-n-propyl-2-thiouracil treated group, (2) granule cell dendrites in both the postnatally 6-n-propyl-2-thiouracil treated and in the hyperthyroid groups and (3) glial processes in the thyroxine treated group comparing to controls.

Original languageEnglish
Pages (from-to)45-57
Number of pages13
JournalNeurobiology
Volume4
Issue number1-2
Publication statusPublished - 1996

Fingerprint

Propylthiouracil
Olfactory Bulb
Thyroid Hormones
Hyperthyroidism
Thyroxine
Neuroglia
Dendrites
Parturition
Antithyroid Agents
Hypothyroidism
Drinking Water
Dendritic Cells
Therapeutics
Electrons
Students
Water

Keywords

  • External plexiform layer
  • Hyperthyroidism
  • Hypothyroidism
  • Morphometry
  • Olfactory bulb

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Modulation by thyroid hormones of the development of external plexiform layer in the rat olfactory bulb. / Hoyk, Z.; Szilagyi, T.; Halasz, N.

In: Neurobiology, Vol. 4, No. 1-2, 1996, p. 45-57.

Research output: Contribution to journalArticle

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