Modulation by GABA of neuroplasticity in the central and peripheral nervous system

J. R. Wolff, F. Joó, P. Kása

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Apart from being a prominent (inhibitory) neurotransmitter that is widely distributed in the central and peripheral nervous system, γ-aminobutyric acid (GABA) has turned out to exert trophic actions. In this manner GABA may modulate the neuroplastic capacity of neurons and neuron-like cells under various conditions in situ and in vitro. In the superior cervical ganglion (SCG) of adult rat, GABA induces the formation of free postsynaptic-like densities on the dendrites of principal neurons and enables implanted foreign (cholinergic) nerves to establish functional synaptic contacts, even while preexisting connections of the preganglionic axons persist. Apart from postsynaptic effects, GABA inhibits acetylcholine release from preganglionic nerve terminals and changes, at least transiently, the neurochemical markers of cholinergic innervation (acetylcholinesterase and nicotinic receptors). In murine neuroblastoma cells in vitro, GABA induces electron microscopic changes, which are similar in principle to those seen in the SCG. Both neuroplastic effects of GABA, in situ and in vitro, could be mimicked by sodium bromide, a hyperpolarizing agent. In addition, evidence is available that GABA via A- and/or B-receptors may exert direct trophic actions. The regulation of both types of trophic actions (direct, receptor-mediated vs. indirect, bioelectric activity dependent) is discussed.

Original languageEnglish
Pages (from-to)453-461
Number of pages9
JournalNeurochemical Research
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 1993

Fingerprint

Neuronal Plasticity
Peripheral Nervous System
Neurology
gamma-Aminobutyric Acid
Central Nervous System
Modulation
Neurons
Superior Cervical Ganglion
Cholinergic Agents
Aminobutyrates
Post-Synaptic Density
Nicotinic Receptors
Acetylcholinesterase
Dendrites
Neuroblastoma
Acetylcholine
Neurotransmitter Agents
Axons
Rats
Electrons

Keywords

  • Autonomic nervous system
  • central nervous system
  • GABAergic innervation
  • trophic effect

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Modulation by GABA of neuroplasticity in the central and peripheral nervous system. / Wolff, J. R.; Joó, F.; Kása, P.

In: Neurochemical Research, Vol. 18, No. 4, 04.1993, p. 453-461.

Research output: Contribution to journalArticle

@article{c944b3c0d5274340b42eb5f5bc638a21,
title = "Modulation by GABA of neuroplasticity in the central and peripheral nervous system",
abstract = "Apart from being a prominent (inhibitory) neurotransmitter that is widely distributed in the central and peripheral nervous system, γ-aminobutyric acid (GABA) has turned out to exert trophic actions. In this manner GABA may modulate the neuroplastic capacity of neurons and neuron-like cells under various conditions in situ and in vitro. In the superior cervical ganglion (SCG) of adult rat, GABA induces the formation of free postsynaptic-like densities on the dendrites of principal neurons and enables implanted foreign (cholinergic) nerves to establish functional synaptic contacts, even while preexisting connections of the preganglionic axons persist. Apart from postsynaptic effects, GABA inhibits acetylcholine release from preganglionic nerve terminals and changes, at least transiently, the neurochemical markers of cholinergic innervation (acetylcholinesterase and nicotinic receptors). In murine neuroblastoma cells in vitro, GABA induces electron microscopic changes, which are similar in principle to those seen in the SCG. Both neuroplastic effects of GABA, in situ and in vitro, could be mimicked by sodium bromide, a hyperpolarizing agent. In addition, evidence is available that GABA via A- and/or B-receptors may exert direct trophic actions. The regulation of both types of trophic actions (direct, receptor-mediated vs. indirect, bioelectric activity dependent) is discussed.",
keywords = "Autonomic nervous system, central nervous system, GABAergic innervation, trophic effect",
author = "Wolff, {J. R.} and F. Jo{\'o} and P. K{\'a}sa",
year = "1993",
month = "4",
doi = "10.1007/BF00967249",
language = "English",
volume = "18",
pages = "453--461",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Modulation by GABA of neuroplasticity in the central and peripheral nervous system

AU - Wolff, J. R.

AU - Joó, F.

AU - Kása, P.

PY - 1993/4

Y1 - 1993/4

N2 - Apart from being a prominent (inhibitory) neurotransmitter that is widely distributed in the central and peripheral nervous system, γ-aminobutyric acid (GABA) has turned out to exert trophic actions. In this manner GABA may modulate the neuroplastic capacity of neurons and neuron-like cells under various conditions in situ and in vitro. In the superior cervical ganglion (SCG) of adult rat, GABA induces the formation of free postsynaptic-like densities on the dendrites of principal neurons and enables implanted foreign (cholinergic) nerves to establish functional synaptic contacts, even while preexisting connections of the preganglionic axons persist. Apart from postsynaptic effects, GABA inhibits acetylcholine release from preganglionic nerve terminals and changes, at least transiently, the neurochemical markers of cholinergic innervation (acetylcholinesterase and nicotinic receptors). In murine neuroblastoma cells in vitro, GABA induces electron microscopic changes, which are similar in principle to those seen in the SCG. Both neuroplastic effects of GABA, in situ and in vitro, could be mimicked by sodium bromide, a hyperpolarizing agent. In addition, evidence is available that GABA via A- and/or B-receptors may exert direct trophic actions. The regulation of both types of trophic actions (direct, receptor-mediated vs. indirect, bioelectric activity dependent) is discussed.

AB - Apart from being a prominent (inhibitory) neurotransmitter that is widely distributed in the central and peripheral nervous system, γ-aminobutyric acid (GABA) has turned out to exert trophic actions. In this manner GABA may modulate the neuroplastic capacity of neurons and neuron-like cells under various conditions in situ and in vitro. In the superior cervical ganglion (SCG) of adult rat, GABA induces the formation of free postsynaptic-like densities on the dendrites of principal neurons and enables implanted foreign (cholinergic) nerves to establish functional synaptic contacts, even while preexisting connections of the preganglionic axons persist. Apart from postsynaptic effects, GABA inhibits acetylcholine release from preganglionic nerve terminals and changes, at least transiently, the neurochemical markers of cholinergic innervation (acetylcholinesterase and nicotinic receptors). In murine neuroblastoma cells in vitro, GABA induces electron microscopic changes, which are similar in principle to those seen in the SCG. Both neuroplastic effects of GABA, in situ and in vitro, could be mimicked by sodium bromide, a hyperpolarizing agent. In addition, evidence is available that GABA via A- and/or B-receptors may exert direct trophic actions. The regulation of both types of trophic actions (direct, receptor-mediated vs. indirect, bioelectric activity dependent) is discussed.

KW - Autonomic nervous system

KW - central nervous system

KW - GABAergic innervation

KW - trophic effect

UR - http://www.scopus.com/inward/record.url?scp=0027538452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027538452&partnerID=8YFLogxK

U2 - 10.1007/BF00967249

DO - 10.1007/BF00967249

M3 - Article

C2 - 8474568

AN - SCOPUS:0027538452

VL - 18

SP - 453

EP - 461

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 4

ER -