ModuLand plug-in for Cytoscape: Determination of hierarchical layers of overlapping network modules and community centrality

M. Szalay, Robin Palotai, Balázs Szappanos, István A. Kovács, B. Papp, P. Csermely

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer represent modules of the lower layer. The tool assigns module cores, which predict the function of the whole module, and determines key nodes bridging two or multiple modules. The plug-in has a detailed JAVA-based graphical interface with various colouring options. The ModuLand tool can run on Windows, Linux or Mac OS. We demonstrate its use on protein structure and metabolic networks.

Original languageEnglish
Article numberbts352
Pages (from-to)2202-2204
Number of pages3
JournalBioinformatics
Volume28
Issue number16
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Centrality
Plug-in
Metabolic Networks and Pathways
Overlapping
Module
Coloring
Proteins
Metabolic Network
Linux
Protein Structure
Vertex of a graph
Colouring
Assign
Community
Predict
Demonstrate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

Cite this

ModuLand plug-in for Cytoscape : Determination of hierarchical layers of overlapping network modules and community centrality. / Szalay, M.; Palotai, Robin; Szappanos, Balázs; Kovács, István A.; Papp, B.; Csermely, P.

In: Bioinformatics, Vol. 28, No. 16, bts352, 08.2012, p. 2202-2204.

Research output: Contribution to journalArticle

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