Módosított hatóanyagleadású intraartikuláris készítmények.

Translated title of the contribution: [Modified release intra-articular drug delivery systems].

Andrea Szabó, Barnabas Szabó, Emese Balogh, R. Zelkó, I. Antal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Beside the many advantages of intraarticular formulations (e.g., the systemic side effects are kept away), there is a big drawback. During the injections, there is the risk for infection therefore the number of injections in a year should be reduced. Also a long-term drug exposure should be achieved with an injection, and if it is possible, a combination of active ingredients should be used. At present there are only formulations with hyaluronic acid or glucocorticoid on the market. One of these formulations, a liposomal preparation, is of sustained drug release. Many different active ingredients could have a long-term drug exposure with carrier systems like micro- and nanoparticles, liposomes, hydrogels and physically activated delivery systems (thermoresponsive or magnetically modulated). The present paper gives an overview about these carrier systems, the novel scientific results and the aim of the future researches, as well.

Original languageHungarian
Pages (from-to)69-74
Number of pages6
JournalActa Pharmaceutica Hungarica
Volume82
Issue number2
Publication statusPublished - 2012

Fingerprint

Drug Delivery Systems
Joints
Injections
Hydrogels
Hyaluronic Acid
Liposomes
Pharmaceutical Preparations
Nanoparticles
Glucocorticoids
Infection
Research

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Módosított hatóanyagleadású intraartikuláris készítmények. / Szabó, Andrea; Szabó, Barnabas; Balogh, Emese; Zelkó, R.; Antal, I.

In: Acta Pharmaceutica Hungarica, Vol. 82, No. 2, 2012, p. 69-74.

Research output: Contribution to journalArticle

Szabó, Andrea ; Szabó, Barnabas ; Balogh, Emese ; Zelkó, R. ; Antal, I. / Módosított hatóanyagleadású intraartikuláris készítmények. In: Acta Pharmaceutica Hungarica. 2012 ; Vol. 82, No. 2. pp. 69-74.
@article{9ba7e768bf6f4c4997e188848c8e3019,
title = "M{\'o}dos{\'i}tott hat{\'o}anyaglead{\'a}s{\'u} intraartikul{\'a}ris k{\'e}sz{\'i}tm{\'e}nyek.",
abstract = "Beside the many advantages of intraarticular formulations (e.g., the systemic side effects are kept away), there is a big drawback. During the injections, there is the risk for infection therefore the number of injections in a year should be reduced. Also a long-term drug exposure should be achieved with an injection, and if it is possible, a combination of active ingredients should be used. At present there are only formulations with hyaluronic acid or glucocorticoid on the market. One of these formulations, a liposomal preparation, is of sustained drug release. Many different active ingredients could have a long-term drug exposure with carrier systems like micro- and nanoparticles, liposomes, hydrogels and physically activated delivery systems (thermoresponsive or magnetically modulated). The present paper gives an overview about these carrier systems, the novel scientific results and the aim of the future researches, as well.",
author = "Andrea Szab{\'o} and Barnabas Szab{\'o} and Emese Balogh and R. Zelk{\'o} and I. Antal",
year = "2012",
language = "Hungarian",
volume = "82",
pages = "69--74",
journal = "Acta Pharmaceutica Hungarica",
issn = "0001-6659",
publisher = "Magyar Gyogyszereszeti Tarsasag",
number = "2",

}

TY - JOUR

T1 - Módosított hatóanyagleadású intraartikuláris készítmények.

AU - Szabó, Andrea

AU - Szabó, Barnabas

AU - Balogh, Emese

AU - Zelkó, R.

AU - Antal, I.

PY - 2012

Y1 - 2012

N2 - Beside the many advantages of intraarticular formulations (e.g., the systemic side effects are kept away), there is a big drawback. During the injections, there is the risk for infection therefore the number of injections in a year should be reduced. Also a long-term drug exposure should be achieved with an injection, and if it is possible, a combination of active ingredients should be used. At present there are only formulations with hyaluronic acid or glucocorticoid on the market. One of these formulations, a liposomal preparation, is of sustained drug release. Many different active ingredients could have a long-term drug exposure with carrier systems like micro- and nanoparticles, liposomes, hydrogels and physically activated delivery systems (thermoresponsive or magnetically modulated). The present paper gives an overview about these carrier systems, the novel scientific results and the aim of the future researches, as well.

AB - Beside the many advantages of intraarticular formulations (e.g., the systemic side effects are kept away), there is a big drawback. During the injections, there is the risk for infection therefore the number of injections in a year should be reduced. Also a long-term drug exposure should be achieved with an injection, and if it is possible, a combination of active ingredients should be used. At present there are only formulations with hyaluronic acid or glucocorticoid on the market. One of these formulations, a liposomal preparation, is of sustained drug release. Many different active ingredients could have a long-term drug exposure with carrier systems like micro- and nanoparticles, liposomes, hydrogels and physically activated delivery systems (thermoresponsive or magnetically modulated). The present paper gives an overview about these carrier systems, the novel scientific results and the aim of the future researches, as well.

UR - http://www.scopus.com/inward/record.url?scp=84865295943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865295943&partnerID=8YFLogxK

M3 - Article

C2 - 22870779

AN - SCOPUS:84865295943

VL - 82

SP - 69

EP - 74

JO - Acta Pharmaceutica Hungarica

JF - Acta Pharmaceutica Hungarica

SN - 0001-6659

IS - 2

ER -