Modified-release capsules containing sodium riboflavin 5'-phosphate

Gyula Buchholcz, András Kelemen, K. Pintye-Hódi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Introduction: The focus of this work was to produce delayed-release capsules containing riboflavin (vitamin B2, as API) layered pellets. Riboflavin therapy is indicated in patients with a riboflavin deficiency, which usually occurs in conjunction with malabsorption, alcoholism or a protein-calorie deficiency and rarely as the sole vitamin deficiency. Riboflavin is readily absorbed from the upper gastrointestinal tract by a specific transport mechanism. The dissolution rate of coated capsules was controlled through the coating of the capsules and the thickness of the coating layer. Methods: The core pellets (Cellet 300) were loaded with a 10% aqueous solution of sodium riboflavin 5'-phosphate by a layering technique in a coating pan. Hard capsules were filled with riboflavin layered pellets and coated with Eudragit NE polymer with different coating layer thicknesses. The dissolution was tested in gastric and intestinal fluids with the half-change method. The dissolution profiles were analyzed with the use of different mathematical models and an attempt was made to predict the optimum coating film thickness that ensures the required degree and rate of dissolution. Results: A new solid dosage form was developed which can enhance the bioavailability of riboflavin. RRSBW distribution and the Chapman-Richards growth function were used to fit the dissolution profiles. Statistical analysis indicated that the best products were described by the Chapman-Richards equation. The results were utilized to create a theoretical model suitable for prediction of the optimum film thickness that ensures the required release of riboflavin.

Original languageEnglish
Pages (from-to)1632-1636
Number of pages5
JournalDrug Development and Industrial Pharmacy
Volume40
Issue number12
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Flavin Mononucleotide
Riboflavin
Capsules
Sodium
Dissolution
Coatings
Theoretical Models
Riboflavin Deficiency
Film thickness
Avitaminosis
Protein Deficiency
Upper Gastrointestinal Tract
Dosage Forms
Biological Availability
Alcoholism
Application programming interfaces (API)
Vitamins
Stomach
Polymers
Statistical methods

Keywords

  • Dissolution
  • Fitting
  • Hard capsule coating
  • Layering technique
  • Theoretical model

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Organic Chemistry
  • Medicine(all)

Cite this

Modified-release capsules containing sodium riboflavin 5'-phosphate. / Buchholcz, Gyula; Kelemen, András; Pintye-Hódi, K.

In: Drug Development and Industrial Pharmacy, Vol. 40, No. 12, 01.12.2014, p. 1632-1636.

Research output: Contribution to journalArticle

Buchholcz, Gyula ; Kelemen, András ; Pintye-Hódi, K. / Modified-release capsules containing sodium riboflavin 5'-phosphate. In: Drug Development and Industrial Pharmacy. 2014 ; Vol. 40, No. 12. pp. 1632-1636.
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