Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit

Botond Gaal, Einar Örn Jóhannesson, Amit Dattani, Agnes Magyar, Ildikó Wéber, C. Matesz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have previously found that unilateral labyrinthectomy is accompanied by modification of hyaluronan and chondroitin sulfate proteoglycan staining in the lateral vestibular nucleus of rats and the time course of subsequent reorganization of extracellular matrix assembly correlates to the restoration of impaired vestibular function. The tenascin-R has repelling effect on pathfinding during axonal growth/regrowth, and thus inhibits neural circuit repair. By using immunohistochemical method, we studied the modification of tenascin-R expression in the superior, medial, lateral, and descending vestibular nuclei of the rat following unilateral labyrinthectomy. On postoperative day 1, tenascin-R reaction in the perineuronal nets disappeared on the side of labyrinthectomy in the superior, lateral, medial, and rostral part of the descending vestibular nuclei. On survival day 3, the staining intensity of tenascin-R reaction in perineuronal nets recovered on the operated side of the medial vestibular nucleus, whereas it was restored by the time of postoperative day 7 in the superior, lateral and rostral part of the descending vestibular nuclei. The staining intensity of tenascin-R reaction remained unchanged in the caudal part of the descending vestibular nucleus bilaterally. Regional differences in the modification of tenascin-R expression presented here may be associated with different roles of individual vestibular nuclei in the compensatory processes. The decreased expression of the tenascin-R may suggest the extracellular facilitation of plastic modifications in the vestibular neural circuit after lesion of the labyrinthine receptors.

Original languageEnglish
Pages (from-to)1463-1470
Number of pages8
JournalNeural Regeneration Research
Volume10
Issue number9
DOIs
Publication statusPublished - 2015

Fingerprint

Neuronal Plasticity
Vestibular Nuclei
Lateral Vestibular Nucleus
Staining and Labeling
Chondroitin Sulfate Proteoglycans
Hyaluronic Acid
tenascin R
Plastics
Extracellular Matrix
Growth

Keywords

  • Brainstem
  • Extracellular matrix
  • Nerve regeneration
  • Neural plasticity
  • Neural regeneration
  • Perineuronal net
  • Vestibular compensation
  • Vestibular lesion
  • Vestibular system

ASJC Scopus subject areas

  • Developmental Neuroscience

Cite this

Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit. / Gaal, Botond; Jóhannesson, Einar Örn; Dattani, Amit; Magyar, Agnes; Wéber, Ildikó; Matesz, C.

In: Neural Regeneration Research, Vol. 10, No. 9, 2015, p. 1463-1470.

Research output: Contribution to journalArticle

Gaal, Botond ; Jóhannesson, Einar Örn ; Dattani, Amit ; Magyar, Agnes ; Wéber, Ildikó ; Matesz, C. / Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit. In: Neural Regeneration Research. 2015 ; Vol. 10, No. 9. pp. 1463-1470.
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