Modification of acute and chronic liver damage by thiazolidine compounds

Divald András, Györgydeák Zoltán, Timar Ferenc, Zalatnai Attila, Bognár Rezsö, Horvath Gábor, Lapis Károly, Jeney András

Research output: Contribution to journalArticle

Abstract

As high sulfhydril levels were shown to reduce the action of agents causing tissue-injury, increasing glutathion concentrations may have cytoprotective potential. In this study the hepatoprotective effects of several derivatives of 4-carboxy-5,5-dimethyl thiazolidine, a modulator of glutathion metabolism were studied in rat liver damaged with CC14. It was found that 4(S) carboxy 5,5-dimethyl-2 (5′-nitro-2-furyl) thiazolidine (dimethyl-thiazolidine-nitrofuran: DTNF) had the most significant hepatoprotective action; therefore it was subjected to detailed investigation in various models for acute and chronic liver injury. This compound was shown to ameliorate allylalcohol induced liver injury in rats, galactosamine induced hepatitis of mice and CC14 induced chronic liver damage in rats. Our study on protein synthesis in primary hepatocyte suspension culture showed that cell injury induced by CCI4 could be reduced in the presence of this thiazolidine compound.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalPathology & Oncology Research
Volume1
Issue number1
DOIs
Publication statusPublished - Mar 1 1995

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Keywords

  • cirrhosis
  • hepatoprotection
  • liver damage
  • thiazolidine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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