The aim of the investigation is to test the feasibility of Ciphergen ProteinChip technology as a proteomic tool in endometriosis research. There were 3 patients with mild endometriosis and 3 patients without endometriosis as control selected in secretory phase (day 20-22) for investigation. 3 endometrium, 3 intact peritoneal biopsies and 3 peritoneal endometriotic lesions, while from controls, 3 endometrium were collected. Endometrial expression was 3-24 times lower in women with endometriosis than without endometriosis between the range of 2.8-12.3kDa protein mass. When compared to normal peritoneum, endometriotic lesions showed an increased expression for a set of proteins in the range of 3-96kDa, and especially an upregulated cluster of proteins between 22-23 kDa. identified to be transgelin, a smooth muscle actin-binding protein.
|Number of pages||6|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jun 14 2007|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology