Modern proteomikai módszer az endometriózis diagnózisának és kórokának tanulmányozására

Translated title of the contribution: Modern proteomical technology in the research and diagnosis of endometriosis

Simsa Péter, Cleophas M. Kyama, Mihályi Attila, Christel Meuleman, Thomas M. D'Hooghe, Fülöp Vilmos

Research output: Contribution to journalArticle

Abstract

The aim of the investigation is to test the feasibility of Ciphergen ProteinChip technology as a proteomic tool in endometriosis research. There were 3 patients with mild endometriosis and 3 patients without endometriosis as control selected in secretory phase (day 20-22) for investigation. 3 endometrium, 3 intact peritoneal biopsies and 3 peritoneal endometriotic lesions, while from controls, 3 endometrium were collected. Endometrial expression was 3-24 times lower in women with endometriosis than without endometriosis between the range of 2.8-12.3kDa protein mass. When compared to normal peritoneum, endometriotic lesions showed an increased expression for a set of proteins in the range of 3-96kDa, and especially an upregulated cluster of proteins between 22-23 kDa. identified to be transgelin, a smooth muscle actin-binding protein.

Original languageHungarian
Pages (from-to)177-182
Number of pages6
JournalMagyar Noorvosok Lapja
Volume70
Issue number3
Publication statusPublished - Jun 14 2007

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ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Péter, S., Kyama, C. M., Attila, M., Meuleman, C., D'Hooghe, T. M., & Vilmos, F. (2007). Modern proteomikai módszer az endometriózis diagnózisának és kórokának tanulmányozására. Magyar Noorvosok Lapja, 70(3), 177-182.