A seminoma korszeru diagnosztikaja es terapiaja

Translated title of the contribution: Modern diagnostics and therapy of seminoma

Research output: Contribution to journalArticle

Abstract

Current principles of diagnostics and therapy of seminoma (40% of all testicular cancers) are reviewed. The 3 pathological types of seminoma are the classical (most frequent), anaplastic, and spermatocytic (rare) variants. Suspected malignancy based on positive results of testicular US investigation calls for obligatory radical orchiectomy through an inguinal incision. The most noteworthy prognostic factor in the clinical course is the tumor burden (in the resected testis and both nodal and distant regions), and exact determination of the anatomical extent of the disease is therefore of paramount importance. The nodal staging is performed by using CT (MRI), which (in conjunction with the chest X-ray) is one of the methods to search for distant metastases. A positive abdominal lymph node finding makes chest/mediastinal CT (MRI) mandatory. Currently, delineation of the extent of the viable tumorous tissue is promoted by PET. The indication, the extent of the irradiated lymph node region(s) and the dosage of postoperative lymphatic irradiation depend on the stage of the disease. During follow-up, the imaging methods as the most important diagnostic tools must be supplemented by physical examination and laboratory investigations (LDH, NSE, β-HCG, AFP, urine analysis and renal function tests). Tumorous dissemination is treated by combined-modality chemotherapy (VPB, BEP and VIP) typically with a curative intention. Establishment of the 95 % mean probability of the long- term cause-specific survival of the adequately treated and followed-up patients is hampered by an incidence of about 5% of radiation-induced, extratesticular secondary tumours and a 2-5 % risk of the appearance of the independent contralateral seminoma. An increased use of prognostic molecular pathological markers, a wider application of 'watch and wait' policy and a more frequent use of adjuvant chemotherapy to the detriment of adjuvant radiotherapy are the predictable trends in the future of diagnosis and therapy of seminoma.

Original languageHungarian
Pages (from-to)21-32
Number of pages12
JournalMagyar Urologia
Volume11
Issue number1
Publication statusPublished - 1999

Fingerprint

Seminoma
Thorax
Lymph Nodes
Lymphatic Irradiation
Adjuvant Radiotherapy
Orchiectomy
Groin
Testicular Neoplasms
Therapeutics
Adjuvant Chemotherapy
Tumor Burden
Physical Examination
Testis
Neoplasms
X-Rays
Urine
Radiation
Neoplasm Metastasis
Kidney
Drug Therapy

ASJC Scopus subject areas

  • Urology

Cite this

A seminoma korszeru diagnosztikaja es terapiaja. / Ésik, O.; Baki, M.; Gundy, S.; Trón, L.; Bodrogi, I.

In: Magyar Urologia, Vol. 11, No. 1, 1999, p. 21-32.

Research output: Contribution to journalArticle

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abstract = "Current principles of diagnostics and therapy of seminoma (40{\%} of all testicular cancers) are reviewed. The 3 pathological types of seminoma are the classical (most frequent), anaplastic, and spermatocytic (rare) variants. Suspected malignancy based on positive results of testicular US investigation calls for obligatory radical orchiectomy through an inguinal incision. The most noteworthy prognostic factor in the clinical course is the tumor burden (in the resected testis and both nodal and distant regions), and exact determination of the anatomical extent of the disease is therefore of paramount importance. The nodal staging is performed by using CT (MRI), which (in conjunction with the chest X-ray) is one of the methods to search for distant metastases. A positive abdominal lymph node finding makes chest/mediastinal CT (MRI) mandatory. Currently, delineation of the extent of the viable tumorous tissue is promoted by PET. The indication, the extent of the irradiated lymph node region(s) and the dosage of postoperative lymphatic irradiation depend on the stage of the disease. During follow-up, the imaging methods as the most important diagnostic tools must be supplemented by physical examination and laboratory investigations (LDH, NSE, β-HCG, AFP, urine analysis and renal function tests). Tumorous dissemination is treated by combined-modality chemotherapy (VPB, BEP and VIP) typically with a curative intention. Establishment of the 95 {\%} mean probability of the long- term cause-specific survival of the adequately treated and followed-up patients is hampered by an incidence of about 5{\%} of radiation-induced, extratesticular secondary tumours and a 2-5 {\%} risk of the appearance of the independent contralateral seminoma. An increased use of prognostic molecular pathological markers, a wider application of 'watch and wait' policy and a more frequent use of adjuvant chemotherapy to the detriment of adjuvant radiotherapy are the predictable trends in the future of diagnosis and therapy of seminoma.",
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