Moderate red wine consumption improves hemorheological parameters in healthy volunteers

A. Toth, B. Sandor, J. Papp, M. Rabai, D. Botor, Zs Horvath, P. Kenyeres, I. Juricskay, K. Toth, L. Czopf

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pieces of epidemiological evidence have supported that moderate red wine consumption reduces the risk of cardiovascular diseases (French-paradox). Our previous in vitro experiment has demonstrated favourable hemorheological effects of red wine, alcohol-free red wine extract and ethanol. Thirty-nine healthy, non-smoking male volunteers between 18-40 years were assigned into two groups: control group had drunk water, while red wine group had consumed 2 dl of red wine each day at dinner for 3 weeks. No alcohol had been drunk for one week prior to the study. Blood was obtained in the morning of the first and last day. Hematocrit (Hct), plasma (PV) and whole blood viscosity (WBV) (Hevimet 40 capillary viscometer), red blood cell (RBC) aggregation (Myrenne and LORCA aggregometer) and deformability (LORCA ektacytometer) were measured and Hct/WBV ratio was calculated to determine oxygen carrying capacity. Hct was adjusted to 40%. Hct and PV were not affected. WBV remained unchanged in controls, but it considerably decreased in the red wine group compared to the 3-week control group, while Hct/WBV ratio became significantly higher in the red wine group compared to the control (p <0.05). RBC aggregation significantly decreased in the red wine group and became significantly lower compared to the 3-week controls (p <0.05). Red wine significantly increased RBC deformability (p <0.05) at high shear stress. Our results show that moderate red wine consumption has beneficial effects on hemorheological parameters which may contribute to the French-paradox.

Original languageEnglish
Pages (from-to)13-23
Number of pages11
JournalClinical Hemorheology and Microcirculation
Volume56
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Wine
Healthy Volunteers
Blood Viscosity
Hematocrit
Cell Aggregation
Erythrocytes
Alcohols
Control Groups
Conservation of Natural Resources
Meals
Volunteers
Ethanol
Cardiovascular Diseases
Oxygen
Water

Keywords

  • Erythrocyte aggregation and deformability
  • Moderate consumption
  • Plasma and whole blood viscosity
  • Red wine

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Moderate red wine consumption improves hemorheological parameters in healthy volunteers. / Toth, A.; Sandor, B.; Papp, J.; Rabai, M.; Botor, D.; Horvath, Zs; Kenyeres, P.; Juricskay, I.; Toth, K.; Czopf, L.

In: Clinical Hemorheology and Microcirculation, Vol. 56, No. 1, 2014, p. 13-23.

Research output: Contribution to journalArticle

Toth, A. ; Sandor, B. ; Papp, J. ; Rabai, M. ; Botor, D. ; Horvath, Zs ; Kenyeres, P. ; Juricskay, I. ; Toth, K. ; Czopf, L. / Moderate red wine consumption improves hemorheological parameters in healthy volunteers. In: Clinical Hemorheology and Microcirculation. 2014 ; Vol. 56, No. 1. pp. 13-23.
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