Modeling the human oxytocin receptor for drug discovery efforts

Balázs Jójárt, Balázs Balogh, A. Márki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The oxytocin receptor belongs to class A receptors great family of G protein-coupled receptors. The endogenous ligand oxytocin is a nonapeptide hormone that induces the uterine contractions at parturition and is used to induce the labor. The peptide oxytocin and, even more, its nonpeptide antagonist, could be valuable tools in tocolysis. The knowledge of the three-dimensional structure of the oxytocin receptor and the determination of the main interaction points between the receptor and the ligands may help to develop selective oxytocin agonists and antagonist. This review summarizes the knowledge about the mapping of the binding domain of the oxytocin receptor and the efforts in the field of molecular modeling studies related to oxytocin receptor-ligand interactions.

Original languageEnglish
Pages (from-to)1579-1590
Number of pages12
JournalExpert Opinion on Drug Discovery
Volume2
Issue number12
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Oxytocin Receptors
Drug Discovery
Oxytocin
Ligands
Tocolysis
Uterine Contraction
G-Protein-Coupled Receptors
Parturition
Hormones
Peptides
human OXTR protein

Keywords

  • Binding domain
  • Molecular docking and dynamics
  • Oxytocin receptor

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Modeling the human oxytocin receptor for drug discovery efforts. / Jójárt, Balázs; Balogh, Balázs; Márki, A.

In: Expert Opinion on Drug Discovery, Vol. 2, No. 12, 12.2007, p. 1579-1590.

Research output: Contribution to journalArticle

Jójárt, Balázs ; Balogh, Balázs ; Márki, A. / Modeling the human oxytocin receptor for drug discovery efforts. In: Expert Opinion on Drug Discovery. 2007 ; Vol. 2, No. 12. pp. 1579-1590.
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