Modeling of the Citric Acid Cycle and its Two Shuttle Systems

Gergely Svab, Gergo Horvath, G. Szederkényi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A dynamical model is proposed in this paper for describing the key quantities of mitochondrial metabolism. Mitochondria are very important cell organelles, because they take part in the bioenergetic functions of the cells, control metabolic pathways, participate in heat production, in upholding the equilibrium of reactive oxygen species, in Ca2+ metabolism, and in the control of apoptotic procedures of the cells. In this work the citric acid cycle and its two transport systems are modeled, namely the malate-aspartate and the citrate-pyruvate shuttle. The overall model containing three modules is given in the form of kinetic ordinary differential equations with 39 state variables. Simulation results are presented and discussed from a biological point of view.

Original languageEnglish
Title of host publicationMED 2018 - 26th Mediterranean Conference on Control and Automation
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages70-77
Number of pages8
ISBN (Print)9781538678909
DOIs
Publication statusPublished - Aug 20 2018
Event26th Mediterranean Conference on Control and Automation, MED 2018 - Zadar, Croatia
Duration: Jun 19 2018Jun 22 2018

Other

Other26th Mediterranean Conference on Control and Automation, MED 2018
CountryCroatia
CityZadar
Period6/19/186/22/18

Fingerprint

Metabolism
Cycle
Mitochondria
Cell
Modeling
Ordinary differential equations
Reactive Oxygen Species
Dynamical Model
Kinetics
Oxygen
Pathway
Ordinary differential equation
Heat
Module
Citric Acid Cycle
Simulation
Model
Energy Metabolism
Hot Temperature
Metabolic Networks and Pathways

ASJC Scopus subject areas

  • Artificial Intelligence
  • Control and Systems Engineering
  • Mechanical Engineering
  • Control and Optimization

Cite this

Svab, G., Horvath, G., & Szederkényi, G. (2018). Modeling of the Citric Acid Cycle and its Two Shuttle Systems. In MED 2018 - 26th Mediterranean Conference on Control and Automation (pp. 70-77). [8442579] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MED.2018.8442579

Modeling of the Citric Acid Cycle and its Two Shuttle Systems. / Svab, Gergely; Horvath, Gergo; Szederkényi, G.

MED 2018 - 26th Mediterranean Conference on Control and Automation. Institute of Electrical and Electronics Engineers Inc., 2018. p. 70-77 8442579.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Svab, G, Horvath, G & Szederkényi, G 2018, Modeling of the Citric Acid Cycle and its Two Shuttle Systems. in MED 2018 - 26th Mediterranean Conference on Control and Automation., 8442579, Institute of Electrical and Electronics Engineers Inc., pp. 70-77, 26th Mediterranean Conference on Control and Automation, MED 2018, Zadar, Croatia, 6/19/18. https://doi.org/10.1109/MED.2018.8442579
Svab G, Horvath G, Szederkényi G. Modeling of the Citric Acid Cycle and its Two Shuttle Systems. In MED 2018 - 26th Mediterranean Conference on Control and Automation. Institute of Electrical and Electronics Engineers Inc. 2018. p. 70-77. 8442579 https://doi.org/10.1109/MED.2018.8442579
Svab, Gergely ; Horvath, Gergo ; Szederkényi, G. / Modeling of the Citric Acid Cycle and its Two Shuttle Systems. MED 2018 - 26th Mediterranean Conference on Control and Automation. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 70-77
@inproceedings{0e0ea4adfaee494bbc7117b1cc9b44e1,
title = "Modeling of the Citric Acid Cycle and its Two Shuttle Systems",
abstract = "A dynamical model is proposed in this paper for describing the key quantities of mitochondrial metabolism. Mitochondria are very important cell organelles, because they take part in the bioenergetic functions of the cells, control metabolic pathways, participate in heat production, in upholding the equilibrium of reactive oxygen species, in Ca2+ metabolism, and in the control of apoptotic procedures of the cells. In this work the citric acid cycle and its two transport systems are modeled, namely the malate-aspartate and the citrate-pyruvate shuttle. The overall model containing three modules is given in the form of kinetic ordinary differential equations with 39 state variables. Simulation results are presented and discussed from a biological point of view.",
author = "Gergely Svab and Gergo Horvath and G. Szederk{\'e}nyi",
year = "2018",
month = "8",
day = "20",
doi = "10.1109/MED.2018.8442579",
language = "English",
isbn = "9781538678909",
pages = "70--77",
booktitle = "MED 2018 - 26th Mediterranean Conference on Control and Automation",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
address = "United States",

}

TY - GEN

T1 - Modeling of the Citric Acid Cycle and its Two Shuttle Systems

AU - Svab, Gergely

AU - Horvath, Gergo

AU - Szederkényi, G.

PY - 2018/8/20

Y1 - 2018/8/20

N2 - A dynamical model is proposed in this paper for describing the key quantities of mitochondrial metabolism. Mitochondria are very important cell organelles, because they take part in the bioenergetic functions of the cells, control metabolic pathways, participate in heat production, in upholding the equilibrium of reactive oxygen species, in Ca2+ metabolism, and in the control of apoptotic procedures of the cells. In this work the citric acid cycle and its two transport systems are modeled, namely the malate-aspartate and the citrate-pyruvate shuttle. The overall model containing three modules is given in the form of kinetic ordinary differential equations with 39 state variables. Simulation results are presented and discussed from a biological point of view.

AB - A dynamical model is proposed in this paper for describing the key quantities of mitochondrial metabolism. Mitochondria are very important cell organelles, because they take part in the bioenergetic functions of the cells, control metabolic pathways, participate in heat production, in upholding the equilibrium of reactive oxygen species, in Ca2+ metabolism, and in the control of apoptotic procedures of the cells. In this work the citric acid cycle and its two transport systems are modeled, namely the malate-aspartate and the citrate-pyruvate shuttle. The overall model containing three modules is given in the form of kinetic ordinary differential equations with 39 state variables. Simulation results are presented and discussed from a biological point of view.

UR - http://www.scopus.com/inward/record.url?scp=85053440097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053440097&partnerID=8YFLogxK

U2 - 10.1109/MED.2018.8442579

DO - 10.1109/MED.2018.8442579

M3 - Conference contribution

AN - SCOPUS:85053440097

SN - 9781538678909

SP - 70

EP - 77

BT - MED 2018 - 26th Mediterranean Conference on Control and Automation

PB - Institute of Electrical and Electronics Engineers Inc.

ER -