Modeling of cell sorting and rare cell capture with microfabricated biodevices

Gabor Jarvas, Andras Guttman

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

In this paper, we review different aspects of computer modeling and simulation of lab-on-a-chip type bioanalytical devices, with special emphasis on cell sorting and rare cell capture, such as circulating tumor cells (CTCs). We critically review important fundamental concepts and innovative applications in addition to detailed analysis by multiphysics approaches. Relevant essentials of hydrodynamic, Newtonian, and non-Newtonian rheological behavior, single and multiphase models, together with various force field-mediated flows are discussed with respect to cell sorting. Furthermore, we provide a summary of techniques used to simulate electric and magnetic field-based rare cell capture methods, such as electrophoresis and magnetophoresis. Finally, we present simulations of practical applications to help non-specialists understand the basic principles and applications.

Original languageEnglish
Pages (from-to)696-703
Number of pages8
JournalTrends in Biotechnology
Volume31
Issue number12
DOIs
Publication statusPublished - Dec 1 2013

Keywords

  • CFD
  • Cell capture
  • Cell sorting
  • Lab-on-a-chip
  • Modeling
  • Simulation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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