Modellvizsgálatok a rákellenes hatású platinakomplexek transzportfolyamatainak értelmezésére

Translated title of the contribution: Model studies on the transport processes of anticancer platinum complexes

Research output: Contribution to journalArticle

Abstract

Potentiometric, calorimetric, NMR and stopped-flow kinetic studies were performed on the palladium(II) complexes of thioether and/or nitrogen donor ligands. The ternary systems always contained a tridentate ligand (dien, dipic, terpy and dianions of dipeptides, GlyGly, GlyAla and GlyMet) and a monodentate thioether (AcMet). The stability constants of thioether complexes were obtained by indirect potentiometric measurements using uridine as a competitive ligand. The thermodynamic parameters revealed that selectivity of palladium(II) for thioether binding can be significantly influenced by the other donor atoms around the metal ion. [Pd(terpy)]2+, [Pd(dipic)]2+ and [Pd(GlyMet)] had the lowest affinity for thioether binding and it was explained by steric and electronic effects. Ternary complexes of nitrogen donors have higher thermodynamic stability constants than that of the thioether complexes, but rate constants of the substitution reactions revealed that the formation of thioether complexes is the faster reaction. As a consequence, the thermodynamic equilibrium state of a multicomponent system is characterized by the coordination of N-donors, which are formed via the existence of thioether bonded intermediates.

Translated title of the contributionModel studies on the transport processes of anticancer platinum complexes
Original languageHungarian
Pages (from-to)211-222
Number of pages12
JournalActa pharmaceutica Hungarica
Volume70
Issue number3-6
Publication statusPublished - Dec 1 2000

ASJC Scopus subject areas

  • Pharmaceutical Science

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