Model-based angiogenic inhibition of tumor growth using modern robust control method

Annamária Szeles, Johanna Sápi, Dániel A. Drexler, István Harmati, Z. Sápi, L. Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Cancer is one of the most destructive and lethal illnesses of the modern civilization. In the last decades, clinical cancer research shifted towards molecular targeted therapies which have limited side effects in comparison to conventional chemotherapy and radiation therapy. Anti-angiogenic therapy is one of the most promising cancer treatment methods. The dynamical model for tumor growth under angiogenic stimulator/inhibitor control was posed by Hahnfeldt et al. (1999), and it was investigated and partly modified many times. In this paper, a modified version of the originally published model is used in order to describe a continuous infusion therapy. To generalize individualized therapies a robust control method is proposed using H methodology. Uncertainty weighting functions are determined based on the real pathophysiological case and simulations are performed on different tumor volumes to demonstrate the robustness of the proposed method.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages113-118
Number of pages6
DOIs
Publication statusPublished - 2012
Event8th IFAC Symposium on Biological and Medical Systems, BMS 2012 - Budapest, Hungary
Duration: Aug 29 2012Aug 31 2012

Other

Other8th IFAC Symposium on Biological and Medical Systems, BMS 2012
CountryHungary
CityBudapest
Period8/29/128/31/12

Fingerprint

Robust control
Tumors
Oncology
Chemotherapy
Radiotherapy
Uncertainty

Keywords

  • Biomedical systems
  • H-infinity optimization
  • Robust control
  • Tumor therapy

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Szeles, A., Sápi, J., Drexler, D. A., Harmati, I., Sápi, Z., & Kovács, L. (2012). Model-based angiogenic inhibition of tumor growth using modern robust control method. In IFAC Proceedings Volumes (IFAC-PapersOnline) (pp. 113-118) https://doi.org/10.3182/20120829-3-HU-2029.00098

Model-based angiogenic inhibition of tumor growth using modern robust control method. / Szeles, Annamária; Sápi, Johanna; Drexler, Dániel A.; Harmati, István; Sápi, Z.; Kovács, L.

IFAC Proceedings Volumes (IFAC-PapersOnline). 2012. p. 113-118.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Szeles, A, Sápi, J, Drexler, DA, Harmati, I, Sápi, Z & Kovács, L 2012, Model-based angiogenic inhibition of tumor growth using modern robust control method. in IFAC Proceedings Volumes (IFAC-PapersOnline). pp. 113-118, 8th IFAC Symposium on Biological and Medical Systems, BMS 2012, Budapest, Hungary, 8/29/12. https://doi.org/10.3182/20120829-3-HU-2029.00098
Szeles A, Sápi J, Drexler DA, Harmati I, Sápi Z, Kovács L. Model-based angiogenic inhibition of tumor growth using modern robust control method. In IFAC Proceedings Volumes (IFAC-PapersOnline). 2012. p. 113-118 https://doi.org/10.3182/20120829-3-HU-2029.00098
Szeles, Annamária ; Sápi, Johanna ; Drexler, Dániel A. ; Harmati, István ; Sápi, Z. ; Kovács, L. / Model-based angiogenic inhibition of tumor growth using modern robust control method. IFAC Proceedings Volumes (IFAC-PapersOnline). 2012. pp. 113-118
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