Model-based angiogenic inhibition of tumor growth using modern robust control method

Annamária Szeles, Johanna Sápi, Dániel A. Drexler, István Harmati, Zoltán Sápi, Levente Kovács

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Cancer is one of the most destructive and lethal illnesses of the modern civilization. In the last decades, clinical cancer research shifted towards molecular targeted therapies which have limited side effects in comparison to conventional chemotherapy and radiation therapy. Anti-angiogenic therapy is one of the most promising cancer treatment methods. The dynamical model for tumor growth under angiogenic stimulator/inhibitor control was posed by Hahnfeldt et al. (1999), and it was investigated and partly modified many times. In this paper, a modified version of the originally published model is used in order to describe a continuous infusion therapy. To generalize individualized therapies a robust control method is proposed using H methodology. Uncertainty weighting functions are determined based on the real pathophysiological case and simulations are performed on different tumor volumes to demonstrate the robustness of the proposed method.

Original languageEnglish
Title of host publicationProceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012
PublisherIFAC Secretariat
Pages113-118
Number of pages6
Edition18
ISBN (Print)9783902823106
DOIs
Publication statusPublished - Jan 1 2012
Event8th IFAC Symposium on Biological and Medical Systems, BMS 2012 - Budapest, Hungary
Duration: Aug 29 2012Aug 31 2012

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
Number18
Volume45
ISSN (Print)1474-6670

Other

Other8th IFAC Symposium on Biological and Medical Systems, BMS 2012
CountryHungary
CityBudapest
Period8/29/128/31/12

Keywords

  • Biomedical systems
  • H-infinity optimization
  • Robust control
  • Tumor therapy

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Szeles, A., Sápi, J., Drexler, D. A., Harmati, I., Sápi, Z., & Kovács, L. (2012). Model-based angiogenic inhibition of tumor growth using modern robust control method. In Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012 (18 ed., pp. 113-118). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 45, No. 18). IFAC Secretariat. https://doi.org/10.3182/20120829-3-HU-2029.00098