Model-based analysis and synthesis of tumor growth under angiogenic inhibition: A case study

Dániel A. Drexler, L. Kovács, Johanna Sápi, István Harmati, Z. Benyó

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Citations (Scopus)

Abstract

Anti-angiogenic therapy is a promising method to fight cancer, however the special therapeutic drugs applied are quite expensive. The aim of this paper is to define simple therapeutical guidelines for sufficient treatment with the usage of the least amount of drugs possible with the help of control theory. We analyze a nonlinear tumor growth model, and use optimal control to design Linear Quadratic controller for offline simulations. The linear model is gained by working point linearization, after the examination of the possible operation points.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Pages3753-3758
Number of pages6
Volume18
EditionPART 1
DOIs
Publication statusPublished - 2011
Event18th IFAC World Congress - Milano, Italy
Duration: Aug 28 2011Sep 2 2011

Other

Other18th IFAC World Congress
CountryItaly
CityMilano
Period8/28/119/2/11

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Tumors
Control theory
Linearization
Controllers

Keywords

  • Biomedical systems
  • LQR control
  • Nonlinear systems
  • Tumor growth

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Drexler, D. A., Kovács, L., Sápi, J., Harmati, I., & Benyó, Z. (2011). Model-based analysis and synthesis of tumor growth under angiogenic inhibition: A case study. In IFAC Proceedings Volumes (IFAC-PapersOnline) (PART 1 ed., Vol. 18, pp. 3753-3758) https://doi.org/10.3182/20110828-6-IT-1002.02107

Model-based analysis and synthesis of tumor growth under angiogenic inhibition : A case study. / Drexler, Dániel A.; Kovács, L.; Sápi, Johanna; Harmati, István; Benyó, Z.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 18 PART 1. ed. 2011. p. 3753-3758.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Drexler, DA, Kovács, L, Sápi, J, Harmati, I & Benyó, Z 2011, Model-based analysis and synthesis of tumor growth under angiogenic inhibition: A case study. in IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 edn, vol. 18, pp. 3753-3758, 18th IFAC World Congress, Milano, Italy, 8/28/11. https://doi.org/10.3182/20110828-6-IT-1002.02107
Drexler DA, Kovács L, Sápi J, Harmati I, Benyó Z. Model-based analysis and synthesis of tumor growth under angiogenic inhibition: A case study. In IFAC Proceedings Volumes (IFAC-PapersOnline). PART 1 ed. Vol. 18. 2011. p. 3753-3758 https://doi.org/10.3182/20110828-6-IT-1002.02107
Drexler, Dániel A. ; Kovács, L. ; Sápi, Johanna ; Harmati, István ; Benyó, Z. / Model-based analysis and synthesis of tumor growth under angiogenic inhibition : A case study. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 18 PART 1. ed. 2011. pp. 3753-3758
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