Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: A long-term experiment

Ferenc Budán, István Szabõ, Tímea Varjas, Ghodratollah Nowrasteh, Tamás Dávid, Péter Gergely, Zsuzsa Varga, Kornélia Molnár, Balázs Kádár, Zsuzsa Orsõs, István Kiss, I. Ember

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A long-term experimental animal model was developed by our research group for the evaluation of potential chemopreventive effects. The inhibitory effects of agents on carcinogen (7,12-dimethylbenz[a]anthracene (DMBA) induced molecular epidemiological biomarkers, in this case the expression of key onco/suppressor genes were investigated. The expression pattern of c-myc, Ha-ras, Bcl-2, K-ras protooncogene and p53 tumour suppressor gene were studied to elucidate early carcinogenic and potential chemopreventive effects. The consumption of so-called Claw of Dragon tea (CoD™ tea) containing the bark of Uncaria guianensis, Cat's Claw (Uncaria sp. U. tomentosa) and Palmer trumpet-tree (Tabebuia sp. T. avellanedae) was able to decrease the DMBA-induced onco/suppressor gene overexpression in a short-term animal experiment. In a following study CBA/Ca mice were treated with 20 mg/kg bw DMBA intraperitoneally (i.p.) and the expression patterns of onco/suppressor genes were examined at several time intervals. According to the examined gene expression patterns in this long-term experiment the chemopreventive effect of CoD™ tea consumption could be confirmed.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalPhytotherapy Research
Volume25
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Tabebuia
Uncaria
Inbred CBA Mouse
Tumor Suppressor Genes
9,10-Dimethyl-1,2-benzanthracene
Hoof and Claw
Tea
Cat's Claw
Carcinogens
Animal Models
Biomarkers
Gene Expression

Keywords

  • carcinogenesis
  • chemoprevention
  • DMBA
  • gene expression
  • Tabebuia
  • Uncaria

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice : A long-term experiment. / Budán, Ferenc; Szabõ, István; Varjas, Tímea; Nowrasteh, Ghodratollah; Dávid, Tamás; Gergely, Péter; Varga, Zsuzsa; Molnár, Kornélia; Kádár, Balázs; Orsõs, Zsuzsa; Kiss, István; Ember, I.

In: Phytotherapy Research, Vol. 25, No. 4, 04.2011, p. 493-500.

Research output: Contribution to journalArticle

Budán, F, Szabõ, I, Varjas, T, Nowrasteh, G, Dávid, T, Gergely, P, Varga, Z, Molnár, K, Kádár, B, Orsõs, Z, Kiss, I & Ember, I 2011, 'Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: A long-term experiment', Phytotherapy Research, vol. 25, no. 4, pp. 493-500. https://doi.org/10.1002/ptr.3281
Budán, Ferenc ; Szabõ, István ; Varjas, Tímea ; Nowrasteh, Ghodratollah ; Dávid, Tamás ; Gergely, Péter ; Varga, Zsuzsa ; Molnár, Kornélia ; Kádár, Balázs ; Orsõs, Zsuzsa ; Kiss, István ; Ember, I. / Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice : A long-term experiment. In: Phytotherapy Research. 2011 ; Vol. 25, No. 4. pp. 493-500.
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