Mixing-models applied to industrial batch bioreactors

B. Mayr, P. Horvat, E. Nagy, A. Moser

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26 Citations (Scopus)


Mixing models for bioreactors on the basis of the tanks-in-series concept are presented and a suitable parameter-estimation method is introduced. The Monte-Carlo-optimization procedure with the inhomogeneity-curve included in the objective function is used. Results of the parameter optimization procedure are given for stirred-tank-bioreactors equipped with one and three Rushton turbines under aerated conditions. The model designed for the stirredtank with three Rushton turbines is capable to describe the mixing properties, while in case of the stirred-tank with one Rushton turbine the simulated radial circulation time does not correlate with the measured one.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalBioprocess Engineering
Issue number1
Publication statusPublished - Mar 1 1993


ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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