Mixed meningeal and brain plasma-cell granuloma

An example of an unusual evolution

Pierre Hughes Roche, D. Figarella-Branger, W. Pellet, F. Isamat, A. Büki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalActa Neurochirurgica
Volume146
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Plasma Cell Granuloma
Brain
Skull Base
Plasma Cells
Seizures
Magnetic Resonance Spectroscopy
Radiotherapy
Steroids
Biopsy
Neoplasms

Keywords

  • Brain pathology
  • Inflammatory pseudotumour
  • Plasmacell granuloma
  • Polyclonal plasma cell proliferation

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Mixed meningeal and brain plasma-cell granuloma : An example of an unusual evolution. / Roche, Pierre Hughes; Figarella-Branger, D.; Pellet, W.; Isamat, F.; Büki, A.

In: Acta Neurochirurgica, Vol. 146, No. 1, 01.2004, p. 69-72.

Research output: Contribution to journalArticle

Roche, Pierre Hughes ; Figarella-Branger, D. ; Pellet, W. ; Isamat, F. ; Büki, A. / Mixed meningeal and brain plasma-cell granuloma : An example of an unusual evolution. In: Acta Neurochirurgica. 2004 ; Vol. 146, No. 1. pp. 69-72.
@article{e3270c4d3c0244b19e16d18302f0a631,
title = "Mixed meningeal and brain plasma-cell granuloma: An example of an unusual evolution",
abstract = "We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.",
keywords = "Brain pathology, Inflammatory pseudotumour, Plasmacell granuloma, Polyclonal plasma cell proliferation",
author = "Roche, {Pierre Hughes} and D. Figarella-Branger and W. Pellet and F. Isamat and A. B{\"u}ki",
year = "2004",
month = "1",
doi = "10.1007/s00701-003-0153-8",
language = "English",
volume = "146",
pages = "69--72",
journal = "Acta Neurochirurgica",
issn = "0001-6268",
publisher = "Springer Wien",
number = "1",

}

TY - JOUR

T1 - Mixed meningeal and brain plasma-cell granuloma

T2 - An example of an unusual evolution

AU - Roche, Pierre Hughes

AU - Figarella-Branger, D.

AU - Pellet, W.

AU - Isamat, F.

AU - Büki, A.

PY - 2004/1

Y1 - 2004/1

N2 - We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.

AB - We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.

KW - Brain pathology

KW - Inflammatory pseudotumour

KW - Plasmacell granuloma

KW - Polyclonal plasma cell proliferation

UR - http://www.scopus.com/inward/record.url?scp=0442309420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0442309420&partnerID=8YFLogxK

U2 - 10.1007/s00701-003-0153-8

DO - 10.1007/s00701-003-0153-8

M3 - Article

VL - 146

SP - 69

EP - 72

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

IS - 1

ER -