Mixed azines of naloxone with dihydromorphinone derivatives

H. Schmidhammer, F. Kaspar, A. Márki, A. Borsodi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The mixed azines 4 and 5 were prepared by reaction of naloxazone (2) with either oxymorphone (6) or 14-O-methyloxymorphone (7) and tested in vitro using opioid receptor binding assays and in vivo using the AcOH-writhing test in mice. Compound 4 was found to be a partial agonist, while compound 5 was a potent opioid agonist with higher potency than morphine.

Original languageEnglish
Pages (from-to)999-1002
Number of pages4
JournalHelvetica Chimica Acta
Volume77
Issue number4
DOIs
Publication statusPublished - 1994

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morphine
Oxymorphone
Hydromorphone
azines
Opioid Receptors
Naloxone
Morphine
Opioid Analgesics
mice
Assays
Derivatives
14-O-methyloxymorphone
naloxazone
In Vitro Techniques

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mixed azines of naloxone with dihydromorphinone derivatives. / Schmidhammer, H.; Kaspar, F.; Márki, A.; Borsodi, A.

In: Helvetica Chimica Acta, Vol. 77, No. 4, 1994, p. 999-1002.

Research output: Contribution to journalArticle

Schmidhammer, H. ; Kaspar, F. ; Márki, A. ; Borsodi, A. / Mixed azines of naloxone with dihydromorphinone derivatives. In: Helvetica Chimica Acta. 1994 ; Vol. 77, No. 4. pp. 999-1002.
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