Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: Mitochondrial targeted preconditioning

David W. Busija, Tamas Gaspar, F. Domoki, Prasad V. Katakam, F. Bari

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Preconditioning represents the condition where transient exposure of cells to an initiating event leads to protection against subsequent, potentially lethal stimuli. Recent studies have established that mitochondrial-centered mechanisms are important mediators in promoting development of the preconditioning response. However, many details concerning these mechanisms are unclear. The purpose of this review is to describe the initiating and subsequent intracellular events involving mitochondria which can lead to neuronal preconditioning. These mitochondrial specific targets include: 1) potassium channels located on the inner mitochondrial membrane; 2) respiratory chain enzymes; and 3) oxidative phosphorylation. Following activation of mitochondrial ATP-sensitive potassium (mitoKATP) channels and/or increased production of reactive oxygen species (ROS) resulting from the disruption of the respiratory chain or during energy substrate deprivation, morphological changes or signaling events involving protein kinases confer immediate or delayed preconditioning on neurons that will allow them to survive otherwise lethal insults. While the mechanisms involved are not known with certainty, the results of preconditioning are the enhanced neuronal viability, the attenuated influx of intracellular calcium, the reduced availability of ROS, the suppression of apoptosis, and the maintenance of ATP levels during and following stress.

Original languageEnglish
Pages (from-to)1471-1477
Number of pages7
JournalAdvanced Drug Delivery Reviews
Volume60
Issue number13-14
DOIs
Publication statusPublished - Oct 2008

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Electron Transport
Reactive Oxygen Species
Neurons
KATP Channels
Potassium Channels
Oxidative Phosphorylation
Mitochondrial Membranes
Protein Kinases
Mitochondria
Adenosine Triphosphate
Maintenance
Apoptosis
Calcium
Enzymes
mitochondrial K(ATP) channel

Keywords

  • Anoxia
  • Apoptosis
  • ATP-sensitive potassium channels
  • Brain
  • Excitotoxicity
  • Ischemia
  • Mitochondria
  • Necrosis
  • Oxygen glucose deprivation

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress : Mitochondrial targeted preconditioning. / Busija, David W.; Gaspar, Tamas; Domoki, F.; Katakam, Prasad V.; Bari, F.

In: Advanced Drug Delivery Reviews, Vol. 60, No. 13-14, 10.2008, p. 1471-1477.

Research output: Contribution to journalArticle

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