Mitochondrial DNA4977 deletion in brain of newborns died after intensive care

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mitochondrial DNA (mtDNA) deletion affecting 4977 base pairs (mtDNA 4977), the most common mtDNA mutation in humans, was analysed in brain specimens (frontal, temporal, and cerebellar cortices, caudate nucleus, thalamus, and hippocampus) and in other tissues (blood clot, liver, kidney, heart, and muscle) taken at autopsy of deceased neonates. mtDNA4977 deletion determined by polymerase chain reaction (PCR) could be demonstrated in each neonatal sample, however, quantity of mtDNA4977 deletion was less in the newborn samples than in those of the elderlies. Results obtained suggest that contrary to certain data mtDNA4977 deletion can be present in neonates. The mtDNA4977 deletion could be generated by perinatal hypoxia or temporary oxygen oversaturations during the intensive care of the neonates, as the mtDNA is sensitive to oxidative damage. In combination with other factors an additional causative role of mtDNA4977 deletion reported here cannot be ruled out in development of cerebral palsy or mental retardation of unknown origin often seen in neonates underwent neonatal intensive care procedures.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalActa Biologica Hungarica
Volume54
Issue number3-4
DOIs
Publication statusPublished - 2003

Fingerprint

neonate
Critical Care
Mitochondrial DNA
brain
Brain
neonates
mitochondrial DNA
Neonatal Intensive Care
Cerebellar Cortex
Caudate Nucleus
Polymerase chain reaction
Frontal Lobe
Cerebral Palsy
Temporal Lobe
Thalamus
Base Pairing
Intellectual Disability
Liver
cerebral palsy
Muscle

Keywords

  • Ageing
  • Brain damage
  • Intensive care
  • Mitochondrial DNA deletion
  • Perinatal hypoxia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Mitochondrial DNA4977 deletion in brain of newborns died after intensive care. / Nádasi, Edit A.; Melegh, B.; Séress, L.; Kosztolányi, G.

In: Acta Biologica Hungarica, Vol. 54, No. 3-4, 2003, p. 253-262.

Research output: Contribution to journalArticle

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