Mitokondriális DNS-deletio vizsgálata újszülöttek agymintáiban.

Translated title of the contribution: Mitochondrial DNA deletions in newborn brain samples

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION: Mitochondrial DNA deletion affecting 4977 base pairs (mtDNA4977) thought to be the most common somatic mutation in man was analysed in samples taken from various parts of the brains at autopsy in order to analyse the supposition whether this mitochondrial damage may play a role in the causation of neurological dysfunction in childhood. METHODS: DNA was isolated from the samples of 15 newborns and 8 adults taken during autopsy. mtDNA4977 deletion was determined by polymerase chain reaction. RESULTS: mtDNA4977 could be demonstrated not only in adults but also in every newborn sample. Estimation of the amount of mtDNA4977 indicated that the level of mtDNA4977 was smaller in the newborn samples than in the elderly's. CONCLUSION: Results suggest that mtDNA4977, contrary to the generally accepted opinion stating that it is acquired during life span, may already be present in the beginning of life. However, the possibility can not be excluded that mutations in the extreme sensitive mtDNA against oxidative damage might be generated by perinatal hypoxia and intensive care. Such a causative role of mtDNA mutations may be an important additional factor in explaining the pathomechanism of cerebral palsy and mental retardation frequently observed in surviving children.

Original languageHungarian
Pages (from-to)1321-1325
Number of pages5
JournalOrvosi Hetilap
Volume145
Issue number25
Publication statusPublished - Jun 20 2004

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Mitochondrial DNA
Base Pairing
Newborn Infant
Brain
Mutation
Autopsy
Beginning of Human Life
Perinatal Care
Cerebral Palsy
Critical Care
Intellectual Disability
Causality
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mitokondriális DNS-deletio vizsgálata újszülöttek agymintáiban. / Nádasi, Edit; Melegh, B.; Séress, L.; Kosztolányi, G.

In: Orvosi Hetilap, Vol. 145, No. 25, 20.06.2004, p. 1321-1325.

Research output: Contribution to journalArticle

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