Mitochondrial changes in preoptic neurones after capsaicin desensitization of the hypothalamic thermodetectors in rats

J. Szolcsányi, F. Joó, Aurelia Jancsó-Gábor

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Abstract

CAPSAICIN, the pungent principle in red pepper (paprika), is a potent irritant causing a sensation of burning pain. After initial violent stimulation, however, this substance induces a selective insensitivity to pain (desensitization) elicited by chemical agents1,2. This long-lasting insensitivity is accompanied by ultrastructural changes in the mitochondria of one type of neurone in the spinal ganglia3.

Original languageEnglish
Pages (from-to)116-117
Number of pages2
JournalNature
Volume229
Issue number5280
DOIs
Publication statusPublished - Dec 1 1971

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