Mitokondrium, oxidatív stressz és öregedés

Translated title of the contribution: Mitochondria, oxidative stress and aging

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The free radical theory of aging was defined in the 1950s. On the base of this theory, the reactive oxygen species formed in the metabolic pathways can play pivotal role in ageing. The theory was modified by defining the mitochondrial respiration as the major cellular source of reactive oxygen species and got the new name mitochondrial theory of aging. Later on the existence of a "vicious cycle" was proposed, in which the reactive oxygen species formed in the mitochondrial respiration impair the mitochondrial DNA and its functions. The formation of reactive oxygen species are elevated due to mitochondrial dysfunction. The formation of mitochondrial DNA mutations can be accelerated by this "vicious cycle", which can lead to accelerated aging. The exonuclease activity of DNA polymerase γ, the polymerase responsible for the replication of mitochondrial DNA was impaired in mtDNA mutator mouse recently. The rate of somatic mutations in mitochondrial DNA was elevated and an aging phenotype could have been observed in these mice. Surprisingly, no oxidative impairment neither elevated reactive oxygen species formation could have been observed in the mtDNA mutator mice, which may question the existence of the "vicious cycle". Orv. Hetil., 2014, 155(12), 447-452.

Original languageHungarian
Pages (from-to)447-452
Number of pages6
JournalOrvosi Hetilap
Volume155
Issue number12
DOIs
Publication statusPublished - 2014

Fingerprint

Mitochondrial DNA
Mitochondria
Oxidative Stress
Reactive Oxygen Species
Respiration
Exonucleases
Mutation Rate
DNA-Directed DNA Polymerase
Metabolic Networks and Pathways
Free Radicals
Names
Phenotype
Mutation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mitokondrium, oxidatív stressz és öregedés. / Szarka, A.; Bánhegyi, G.; Sümegi, B.

In: Orvosi Hetilap, Vol. 155, No. 12, 2014, p. 447-452.

Research output: Contribution to journalArticle

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AB - The free radical theory of aging was defined in the 1950s. On the base of this theory, the reactive oxygen species formed in the metabolic pathways can play pivotal role in ageing. The theory was modified by defining the mitochondrial respiration as the major cellular source of reactive oxygen species and got the new name mitochondrial theory of aging. Later on the existence of a "vicious cycle" was proposed, in which the reactive oxygen species formed in the mitochondrial respiration impair the mitochondrial DNA and its functions. The formation of reactive oxygen species are elevated due to mitochondrial dysfunction. The formation of mitochondrial DNA mutations can be accelerated by this "vicious cycle", which can lead to accelerated aging. The exonuclease activity of DNA polymerase γ, the polymerase responsible for the replication of mitochondrial DNA was impaired in mtDNA mutator mouse recently. The rate of somatic mutations in mitochondrial DNA was elevated and an aging phenotype could have been observed in these mice. Surprisingly, no oxidative impairment neither elevated reactive oxygen species formation could have been observed in the mtDNA mutator mice, which may question the existence of the "vicious cycle". Orv. Hetil., 2014, 155(12), 447-452.

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