Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: A new and improved trap for the detection of superoxide

Micael Hardy, Florence Chalier, Olivier Ouari, Jean Pierre Finet, Antal Rockenbauer, Balaraman Kalyanaraman, Paul Tordo

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Mito-DEPMPO, a new DEPMPO analogue bearing a triphenylphosphonium group, was synthesized via a novel NH2-reactive DEPMPO. The half-life of the Mito-DEPMPO superoxide adduct was estimated to be ca. 40 min. Using Mito-DEPMPO, reactive oxygen species generated in intact mitochondria were detected and characterized by EPR.

Original languageEnglish
Pages (from-to)1083-1085
Number of pages3
JournalChemical Communications
Issue number10
DOIs
Publication statusPublished - Jan 1 2007

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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