MiR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5

Edit Miko, Zoltán Margitai, Zsolt Czimmerer, Ildikó Várkonyi, Balázs Dezs, Árpád Lányi, Zsolt Bacsó, Beáta Scholtz

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Despite intensive efforts to improve therapies, small cell lung cancer (SCLC) still has a dismal median survival of 18 months. Since miR-126 is under-expressed in the majority of SCLC tumors, we investigated the effect of miR-126 overexpression on the proliferation and cell cycle distribution of H69 cells. Our results demonstrate that miR-126 inhibits proliferation of H69 cells, by delaying the cells in the G1 phase. Short interfering RNA (siRNA) mediated suppression of SLC7A5, a predicted target of mir-126, has the same effect on H69 cells. We also show for the first time that SLC7A5 is a direct target of miR-126.

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalFEBS letters
Volume585
Issue number8
DOIs
Publication statusPublished - Apr 20 2011

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Keywords

  • G1 delay
  • SLC7A5
  • Small cell lung cancer
  • miR-126

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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