Minor physical anomalies are more common among the first-degree unaffected relatives of schizophrenia patients - Results with the Méhes Scale

András Hajnal, Györgyi Csábi, Róbert Herold, Sára Jeges, Tamás Halmai, Dániel Trixler, Maria Simon, Ákos Levente Tóth, Tamás Tényi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Minor physical anomalies are external markers of abnormal brain development,so the more common appearance of these signs among the relatives of schizophrenia patients can confirm minor physical anomalies as intermediate phenotypes. The aim of the present study was to investigate the rate and topological profile of minor physical anomalies in the first-degree unaffected relatives of patients with schizophrenia compared to matched normal control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 20 relatives of patients with the diagnosis of schizophrenia and as a comparison 20 matched normal control subjects were examined. Minor physical anomalies were more common in the head and mouth regions among the relatives of schizophrenia patients compared to normal controls. By the differentiation of minor malformations and phenogenetic variants, we have found that only phenogenetic variants were more common in the relatives of schizophrenia patients compared to the control group, however individual analyses showed, that one minor malformation (flat forehead) was more prevalent in the relative group. The results can promote the concept, that minor physical anomalies can be endophenotypic markers of the illness.

Original languageEnglish
Pages (from-to)224-228
Number of pages5
JournalPsychiatry research
Volume237
DOIs
Publication statusPublished - Mar 30 2016

Keywords

  • Endophenotype
  • Neurodevelopment
  • Psychotic disorders
  • Somatic markers

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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