Minor malformations in mental retardation of various aetiology

V. Meggyessy, M. Revhelyi, K. Méhes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The frequency of minor malformations was determined in 246 mentally retarded children with an IQ ranging from 37 to 67. According to the probable etiology, the patients were divided into 4 groups: Down syndrome (n=29), other genetic causes (n=22), perinatal and postnatal environmental damage (n=68), and unknown etiology (n=127). One thousand consecutive newborn infants served as controls. The mean number of minor malformations per subject was the highest in patients with Down syndrome (3.38) and other genetic disorders (2.00). It was significantly lower in the mentally handicapped of unknown (0.88) and of environmental origin (0.37). The number of multiple minor anomalies was high in the genetically determined conditions and smallest, nearing the control value, in the exogenic group. The results support the idea that the presence of minor malformations, and especially of multiple ones, refers to the prenatal onset of mental deficiency.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalActa Paediatrica Academiae Scientiarum Hungaricae
Volume21
Issue number2-3
Publication statusPublished - 1980

Fingerprint

Mentally Disabled Persons
Down Syndrome
Intellectual Disability
Inborn Genetic Diseases
Newborn Infant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Minor malformations in mental retardation of various aetiology. / Meggyessy, V.; Revhelyi, M.; Méhes, K.

In: Acta Paediatrica Academiae Scientiarum Hungaricae, Vol. 21, No. 2-3, 1980, p. 175-180.

Research output: Contribution to journalArticle

@article{e384f2f4076e448c9074e16310aad1e0,
title = "Minor malformations in mental retardation of various aetiology",
abstract = "The frequency of minor malformations was determined in 246 mentally retarded children with an IQ ranging from 37 to 67. According to the probable etiology, the patients were divided into 4 groups: Down syndrome (n=29), other genetic causes (n=22), perinatal and postnatal environmental damage (n=68), and unknown etiology (n=127). One thousand consecutive newborn infants served as controls. The mean number of minor malformations per subject was the highest in patients with Down syndrome (3.38) and other genetic disorders (2.00). It was significantly lower in the mentally handicapped of unknown (0.88) and of environmental origin (0.37). The number of multiple minor anomalies was high in the genetically determined conditions and smallest, nearing the control value, in the exogenic group. The results support the idea that the presence of minor malformations, and especially of multiple ones, refers to the prenatal onset of mental deficiency.",
author = "V. Meggyessy and M. Revhelyi and K. M{\'e}hes",
year = "1980",
language = "English",
volume = "21",
pages = "175--180",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Verlag",
number = "2-3",

}

TY - JOUR

T1 - Minor malformations in mental retardation of various aetiology

AU - Meggyessy, V.

AU - Revhelyi, M.

AU - Méhes, K.

PY - 1980

Y1 - 1980

N2 - The frequency of minor malformations was determined in 246 mentally retarded children with an IQ ranging from 37 to 67. According to the probable etiology, the patients were divided into 4 groups: Down syndrome (n=29), other genetic causes (n=22), perinatal and postnatal environmental damage (n=68), and unknown etiology (n=127). One thousand consecutive newborn infants served as controls. The mean number of minor malformations per subject was the highest in patients with Down syndrome (3.38) and other genetic disorders (2.00). It was significantly lower in the mentally handicapped of unknown (0.88) and of environmental origin (0.37). The number of multiple minor anomalies was high in the genetically determined conditions and smallest, nearing the control value, in the exogenic group. The results support the idea that the presence of minor malformations, and especially of multiple ones, refers to the prenatal onset of mental deficiency.

AB - The frequency of minor malformations was determined in 246 mentally retarded children with an IQ ranging from 37 to 67. According to the probable etiology, the patients were divided into 4 groups: Down syndrome (n=29), other genetic causes (n=22), perinatal and postnatal environmental damage (n=68), and unknown etiology (n=127). One thousand consecutive newborn infants served as controls. The mean number of minor malformations per subject was the highest in patients with Down syndrome (3.38) and other genetic disorders (2.00). It was significantly lower in the mentally handicapped of unknown (0.88) and of environmental origin (0.37). The number of multiple minor anomalies was high in the genetically determined conditions and smallest, nearing the control value, in the exogenic group. The results support the idea that the presence of minor malformations, and especially of multiple ones, refers to the prenatal onset of mental deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0019199728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019199728&partnerID=8YFLogxK

M3 - Article

C2 - 6451141

AN - SCOPUS:0019199728

VL - 21

SP - 175

EP - 180

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 2-3

ER -