Mimosine, a Plant-derived Amino Acid Induces Apoptosis in Human Pancreatic Cancer Xenografts

A. Zalatnai, Jozsef Bocsi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Several studies have indicated that mimosine, a plant amino acid, is a potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. These results were mainly derived from in vitro investigations. To date only one paper is available about its applicability in xenografted lung tumor. This study revealed a tumor growth suppression and an increased apoptotic index. Our experiment was aimed at investigating the influence of mimosine in human pancreatic cancer. Materials and Methods: Subcutaneously growing human pancreatic cancer xenografts in immunosuppressed mice were treated with 30 mg/kg b.w. mimosine for 34 days and the apoptosis was assessed by flow cytometry. Results: Mimosine treatment resulted in a significant tumor growth suppression and the sub-G1 fraction was doubled (10.82±1.18% vs. 4.65±1.65 % in controls, p <0.01). Conclusion: This is the first evidence that mimosine exerts an apoptotic activity in xenotransplanted human pancreatic cancer and suppresses its growth.

Original languageEnglish
Pages (from-to)4007-4010
Number of pages4
JournalAnticancer Research
Volume23
Issue number5 A
Publication statusPublished - Sep 2003

Fingerprint

Mimosine
Pancreatic Neoplasms
Heterografts
Apoptosis
Amino Acids
Growth
Neoplasms
G1 Phase
Cell Cycle
Flow Cytometry
Lung

Keywords

  • Apoptosis
  • Flow cytometry
  • Mimosine
  • Pancreatic cancer
  • Xenograft

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mimosine, a Plant-derived Amino Acid Induces Apoptosis in Human Pancreatic Cancer Xenografts. / Zalatnai, A.; Bocsi, Jozsef.

In: Anticancer Research, Vol. 23, No. 5 A, 09.2003, p. 4007-4010.

Research output: Contribution to journalArticle

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