Mild palladium-catalyzed oxidative direct ortho-C-H acylation of anilides under aqueous conditions

Fruzsina Szabõ, János Daru, Dániel Simkõ, Tibor Zs Nagy, András Stirling, Zoltán Novák

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62 Citations (Scopus)


Palladium-catalyzed cross-dehydrogenative coupling between anilides and aromatic aldehydes was achieved under aqueous conditions. A wide variety of the desired benzophenone derivatives was isolated in good to excellent yield. The reaction rate acceleration effect of acid and detergent has been demonstrated. Mechanistic insight has been obtained from quantum chemical calculations.

Original languageEnglish
Pages (from-to)685-691
Number of pages7
JournalAdvanced Synthesis and Catalysis
Issue number4
Publication statusPublished - Mar 11 2013



  • C-H activation
  • acylation
  • aldehydes
  • palladium
  • surfactants

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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