Migraine and risk of cardiovascular diseases: Danish population based matched cohort study

Kasper Adelborg, Szimonetta Komjáthiné Szépligeti, Louise Holland-Bill, Vera Ehrenstein, Erzsébet Horváth-Puhó, Victor W. Henderson, Henrik Toft Sørensen

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort.

DESIGN: Nationwide, population based cohort study.

SETTING: All Danish hospitals and hospital outpatient clinics from 1995 to 2013.

PARTICIPANTS: 51 032 patients with migraine and 510 320 people from the general population matched on age, sex, and calendar year.

MAIN OUTCOME MEASURES: Comorbidity adjusted hazard ratios of cardiovascular outcomes based on Cox regression analysis.

RESULTS: Higher absolute risks were observed among patients with incident migraine than in the general population across most outcomes and follow-up periods. After 19 years of follow-up, the cumulative incidences per 1000 people for the migraine cohort compared with the general population were 25 v 17 for myocardial infarction, 45 v 25 for ischaemic stroke, 11 v 6 for haemorrhagic stroke, 13 v 11 for peripheral artery disease, 27 v 18 for venous thromboembolism, 47 v 34 for atrial fibrillation or atrial flutter, and 19 v 18 for heart failure. Correspondingly, migraine was positively associated with myocardial infarction (adjusted hazard ratio 1.49, 95% confidence interval 1.36 to 1.64), ischaemic stroke (2.26, 2.11 to 2.41), and haemorrhagic stroke (1.94, 1.68 to 2.23), as well as venous thromboembolism (1.59, 1.45 to 1.74) and atrial fibrillation or atrial flutter (1.25, 1.16 to 1.36). No meaningful association was found with peripheral artery disease (adjusted hazard ratio 1.12, 0.96 to 1.30) or heart failure (1.04, 0.93 to 1.16). The associations, particularly for stroke outcomes, were stronger during the short term (0-1 years) after diagnosis than the long term (up to 19 years), in patients with aura than in those without aura, and in women than in men. In a subcohort of patients, the associations persisted after additional multivariable adjustment for body mass index and smoking.

CONCLUSIONS: Migraine was associated with increased risks of myocardial infarction, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, and atrial fibrillation or atrial flutter. Migraine may be an important risk factor for most cardiovascular diseases.

Original languageEnglish
Pages (from-to)k96
JournalBMJ (Clinical research ed.)
Volume360
DOIs
Publication statusPublished - Jan 31 2018

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Migraine Disorders
Cohort Studies
Cardiovascular Diseases
Stroke
Atrial Flutter
Venous Thromboembolism
Atrial Fibrillation
Population
Peripheral Arterial Disease
Myocardial Infarction
Heart Failure
Epilepsy
Hospital Outpatient Clinics
Comorbidity
Body Mass Index
Smoking
Regression Analysis
Confidence Intervals
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Adelborg, K., Szépligeti, S. K., Holland-Bill, L., Ehrenstein, V., Horváth-Puhó, E., Henderson, V. W., & Sørensen, H. T. (2018). Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ (Clinical research ed.), 360, k96. https://doi.org/10.1136/bmj.k96

Migraine and risk of cardiovascular diseases : Danish population based matched cohort study. / Adelborg, Kasper; Szépligeti, Szimonetta Komjáthiné; Holland-Bill, Louise; Ehrenstein, Vera; Horváth-Puhó, Erzsébet; Henderson, Victor W.; Sørensen, Henrik Toft.

In: BMJ (Clinical research ed.), Vol. 360, 31.01.2018, p. k96.

Research output: Contribution to journalArticle

Adelborg, K, Szépligeti, SK, Holland-Bill, L, Ehrenstein, V, Horváth-Puhó, E, Henderson, VW & Sørensen, HT 2018, 'Migraine and risk of cardiovascular diseases: Danish population based matched cohort study', BMJ (Clinical research ed.), vol. 360, pp. k96. https://doi.org/10.1136/bmj.k96
Adelborg, Kasper ; Szépligeti, Szimonetta Komjáthiné ; Holland-Bill, Louise ; Ehrenstein, Vera ; Horváth-Puhó, Erzsébet ; Henderson, Victor W. ; Sørensen, Henrik Toft. / Migraine and risk of cardiovascular diseases : Danish population based matched cohort study. In: BMJ (Clinical research ed.). 2018 ; Vol. 360. pp. k96.
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AU - Horváth-Puhó, Erzsébet

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N2 - OBJECTIVE: To examine the risks of myocardial infarction, stroke (ischaemic and haemorrhagic), peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter, and heart failure in patients with migraine and in a general population comparison cohort.DESIGN: Nationwide, population based cohort study.SETTING: All Danish hospitals and hospital outpatient clinics from 1995 to 2013.PARTICIPANTS: 51 032 patients with migraine and 510 320 people from the general population matched on age, sex, and calendar year.MAIN OUTCOME MEASURES: Comorbidity adjusted hazard ratios of cardiovascular outcomes based on Cox regression analysis.RESULTS: Higher absolute risks were observed among patients with incident migraine than in the general population across most outcomes and follow-up periods. After 19 years of follow-up, the cumulative incidences per 1000 people for the migraine cohort compared with the general population were 25 v 17 for myocardial infarction, 45 v 25 for ischaemic stroke, 11 v 6 for haemorrhagic stroke, 13 v 11 for peripheral artery disease, 27 v 18 for venous thromboembolism, 47 v 34 for atrial fibrillation or atrial flutter, and 19 v 18 for heart failure. Correspondingly, migraine was positively associated with myocardial infarction (adjusted hazard ratio 1.49, 95% confidence interval 1.36 to 1.64), ischaemic stroke (2.26, 2.11 to 2.41), and haemorrhagic stroke (1.94, 1.68 to 2.23), as well as venous thromboembolism (1.59, 1.45 to 1.74) and atrial fibrillation or atrial flutter (1.25, 1.16 to 1.36). No meaningful association was found with peripheral artery disease (adjusted hazard ratio 1.12, 0.96 to 1.30) or heart failure (1.04, 0.93 to 1.16). The associations, particularly for stroke outcomes, were stronger during the short term (0-1 years) after diagnosis than the long term (up to 19 years), in patients with aura than in those without aura, and in women than in men. In a subcohort of patients, the associations persisted after additional multivariable adjustment for body mass index and smoking.CONCLUSIONS: Migraine was associated with increased risks of myocardial infarction, ischaemic stroke, haemorrhagic stroke, venous thromboembolism, and atrial fibrillation or atrial flutter. Migraine may be an important risk factor for most cardiovascular diseases.

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