MIF tautomerase inhibitor potency of α,β-unsaturated cyclic ketones

János Garai, Valéria Molnár, Dániel Eros, L. Őrfi, T. Lóránd

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pro-inflammatory cytokine, macrophage migration inhibitory factor (MIF), is currently enjoying a renewed interest owing to its recently revealed functions. Among these its enzymatic tautomerase activity remains the most perplexing. There is a notion that some aspects of MIF signaling might involve its catalytic action. Though a true in vivo substrate for MIF has not been identified yet small molecule inhibitors of MIF are sought currently as potential anti-inflammatory agents. We have reported earlier that ketone bodies and some plant phenols feature acidic CH groups that appear to be good markers of their inhibitor potency toward MIF phenylpyruvate tautomerase. These molecules, like phenylpyruvate itself, belong to the keto-carboxylic acids or to the α,β-unsaturated ketones. Some ketones of similar structure have earlier been reported to have anti-inflammatory effect. In this paper we report tautomerase inhibition by certain synthetic α,β-unsaturated cyclic ketones, a novel class of small molecule MIF inhibitors.

Original languageEnglish
Pages (from-to)1741-1746
Number of pages6
JournalInternational Immunopharmacology
Volume7
Issue number13
DOIs
Publication statusPublished - Dec 15 2007

Fingerprint

Ketones
Anti-Inflammatory Agents
Macrophage Migration-Inhibitory Factors
Keto Acids
Ketone Bodies
Phenols
Carboxylic Acids
Cytokines

Keywords

  • α,β-unsaturated ketone
  • Curcumin
  • Inflammation
  • Macrophage migration inhibitory factor
  • MIF
  • Tautomerase

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

MIF tautomerase inhibitor potency of α,β-unsaturated cyclic ketones. / Garai, János; Molnár, Valéria; Eros, Dániel; Őrfi, L.; Lóránd, T.

In: International Immunopharmacology, Vol. 7, No. 13, 15.12.2007, p. 1741-1746.

Research output: Contribution to journalArticle

Garai, János ; Molnár, Valéria ; Eros, Dániel ; Őrfi, L. ; Lóránd, T. / MIF tautomerase inhibitor potency of α,β-unsaturated cyclic ketones. In: International Immunopharmacology. 2007 ; Vol. 7, No. 13. pp. 1741-1746.
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