Microwave-assisted synthesis of N,N-bis(phosphinoylmethyl)amines and N,N,N-tris(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms

Erika Bálint, Anna Tripolszky, László Hegedűs, György Keglevich

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A family of N,N-bis(phosphinoylmethyl)amines bearing different substituents on the phosphorus atoms was synthesized by the microwave-assisted and catalyst-free Kabachnik–Fields reaction of (aminomethyl)phosphine oxides with paraformaldehyde and diphenylphosphine oxide. The three-component condensation of N,N-bis(phosphinoylmethyl)amine, paraformaldehyde and a secondary phosphine oxide affording N,N,N-tris(phosphinoylmethyl)amine derivatives was also elaborated. This method is a novel approach for the synthesis of the target products.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalBeilstein Journal of Organic Chemistry
Volume15
DOIs
Publication statusPublished - Feb 15 2019

Keywords

  • (aminomethyl)phosphine oxides
  • Kabachnik–Fields reaction
  • Ligand
  • Microwave
  • N,N,N-tris(phosphinoylmethyl)amines
  • N,N-bis(phosphinoylmethyl)amines

ASJC Scopus subject areas

  • Organic Chemistry

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