A practical method was elaborated for the synthesis of (aminomethylene)bisphosphine oxides comprising the catalyst- and solventfree microwave-assisted three-component condensation of primary amines, triethyl orthoformate and two equivalents of diphenylphosphine oxide. The method is also suitable for the preparation of (aminomethylene)bisphosphonates using (MeO)2 P(O)H/(MeO)3CH or (EtO)2P(O)H/(EtO) 3CH reactant pairs and even secondary amines. Several intermediates referring to the reaction mechanism together with a few by-products could also be identified.
- Aminomethylenebisphosphine oxides
- Three-component condensation
ASJC Scopus subject areas
- Organic Chemistry