Microwave-assisted synthesis of (aminomethylene)bisphosphine oxides and (aminomethylene)bisphosphonates by a three-component condensation

Erika Bálint, Ádám Tajti, Anna Dzielak, Gerhard Hägele, György Keglevich

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Abstract

A practical method was elaborated for the synthesis of (aminomethylene)bisphosphine oxides comprising the catalyst- and solventfree microwave-assisted three-component condensation of primary amines, triethyl orthoformate and two equivalents of diphenylphosphine oxide. The method is also suitable for the preparation of (aminomethylene)bisphosphonates using (MeO)2 P(O)H/(MeO)3CH or (EtO)2P(O)H/(EtO) 3CH reactant pairs and even secondary amines. Several intermediates referring to the reaction mechanism together with a few by-products could also be identified.

Original languageEnglish
Pages (from-to)1493-1502
Number of pages10
JournalBeilstein Journal of Organic Chemistry
Volume12
DOIs
Publication statusPublished - Jul 19 2016

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Keywords

  • Aminomethylenebisphosphine oxides
  • Aminomethylenebisphosphonates
  • Microwave
  • Three-component condensation

ASJC Scopus subject areas

  • Organic Chemistry

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