Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik–Fields reaction applying amides as the starting materials

Anna Tripolszky, Lili Zoboki, Erika Bálint, János Kóti, György Keglevich

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of acylated α-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik–Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the –NH2 reagents, they had to be used in an excess. The solvolytic condensations furnished the α-aminophosphine oxides in yields of 58–93% after purification by chromatography.

Original languageEnglish
Pages (from-to)1047-1054
Number of pages8
JournalSynthetic Communications
Volume49
Issue number8
DOIs
Publication statusPublished - Apr 18 2019

Keywords

  • Kabachnik–Fields reaction
  • carboxylic acid amides
  • microwave
  • α-Aminophosphine oxides

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik–Fields reaction applying amides as the starting materials'. Together they form a unique fingerprint.

  • Cite this