Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik–Fields reaction applying amides as the starting materials

Anna Tripolszky, Lili Zoboki, Erika Bálint, János Kóti, G. Keglevich

Research output: Contribution to journalArticle

Abstract

A series of acylated α-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik–Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the –NH 2 reagents, they had to be used in an excess. The solvolytic condensations furnished the α-aminophosphine oxides in yields of 58–93% after purification by chromatography.

Original languageEnglish
JournalSynthetic Communications
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Amides
Oxides
phosphine
Microwaves
Carboxylic Acids
Chromatography
Formaldehyde
Purification
Condensation

Keywords

  • carboxylic acid amides
  • Kabachnik–Fields reaction
  • microwave
  • α-Aminophosphine oxides

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik–Fields reaction applying amides as the starting materials. / Tripolszky, Anna; Zoboki, Lili; Bálint, Erika; Kóti, János; Keglevich, G.

In: Synthetic Communications, 01.01.2019.

Research output: Contribution to journalArticle

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