A fokozott arrhythmiarizikó új markere: A mikrovolt T-hullám-alternáns patomechanizmusa és vizsgálati módszerei

Translated title of the contribution: Microvolt T-wave alternant: Pathomechanism and evaluation of a new marker of arrhythmia risk

István Lorincz, Eszter Szánthó, József Simkó, Zoltán Szabó, Kitti Barta, Márta Füzi, Gyula Szigeti

Research output: Contribution to journalReview article

Abstract

Microvolt T-wave alternant (μV-TWA) is a beat-to-beat fluctuation in the amplitude of T-wave at a microvolt level. The amount of variation is small, on the order of microvolts, so sensitive digital signal processing techniques are required to detect μV-TWA. The appearance of μV-TWA has been suggested as a predictor of susceptibility to lethal ventricular tachyarrhythmias, and sudden cardiac death in different patients' populations. During the last decade, theoretical, experimental and clinical research efforts have focused primarily on μV-TWA, examining its mechanisms and predictive value using time-invariant cutoff values. The cellular mechanisms involved are not well-defined and are the subject of this investigation. This review discusses the bench-to-bedside literature that, over decades, has linked alternans of repolarization in cellular, whole-heart, and human studies with spatial dispersion of repolarization, alternans of cellular action potential, and fluctuations in ionic currents, intracellular calcium regulation, role of the beta adrenergic receptors and connexins that may lead to ventricular arrhythmias. This review then provides a contemporary framework for the use of μV-TWA methods to enhance risk stratification for sudden cardiac death, identifying populations for whom μV-TWA is best established.

Original languageHungarian
Pages (from-to)1215-1224
Number of pages10
JournalOrvosi hetilap
Volume151
Issue number30
DOIs
Publication statusPublished - Jul 1 2010

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ASJC Scopus subject areas

  • Medicine(all)

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