Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology

Victoria C. Ridger, Chantal M. Boulanger, Anne Angelillo-Scherrer, Lina Badimon, Olivier Blanc-Brude, Marie Luce Bochaton-Piallat, Eric Boilard, E. Búzás, Andreas Caporali, Francoise Dignat-George, Paul C. Evans, Romaric Lacroix, Esther Lutgens, Daniel F.J. Ketelhuth, Rienk Nieuwland, Florence Toti, Jose Tuñon, Christian Weber, Imo E. Hoefer, Gregory Y.H. Lip & 5 others Nikos Werner, Eduard Shantsila, Hugo ten Cate, Mark Thomas, Paul Harrison

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Microvesicles are members of the family of extracellular vesicles shed from the plasma membrane of activated or apoptotic cells. Microvesicles were initially characterised by their pro-coagulant activity and described as “microparticles”. There is mounting evidence revealing a role for microvesicles in intercellular communication, with particular relevance to hemostasis and vascular biology. Coupled with this, the potential of microvesicles as meaningful biomarkers is under intense investigation. This Position Paper will summarise the current knowledge on the mechanisms of formation and composition of microvesicles of endothelial, platelet, red blood cell and leukocyte origin. This paper will also review and discuss the different methods used for their analysis and quantification, will underline the potential biological roles of these vesicles with respect to vascular homeostasis and thrombosis and define important themes for future research.

Original languageEnglish
Pages (from-to)1296-1316
Number of pages21
JournalThrombosis and Haemostasis
Volume117
Issue number7
DOIs
Publication statusPublished - Jan 1 2017

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Cardiology
Vascular Diseases
Blood Vessels
Atherosclerosis
Homeostasis
Coagulants
Hemostasis
Thrombosis
Leukocytes
Blood Platelets
Erythrocytes
Biomarkers
Cell Membrane
Extracellular Vesicles

Keywords

  • Atherothrombosis
  • Cell-cell interactions
  • Inflammatory mediators
  • Macrophage

ASJC Scopus subject areas

  • Hematology

Cite this

Ridger, V. C., Boulanger, C. M., Angelillo-Scherrer, A., Badimon, L., Blanc-Brude, O., Bochaton-Piallat, M. L., ... Harrison, P. (2017). Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology. Thrombosis and Haemostasis, 117(7), 1296-1316. https://doi.org/10.1160/TH16-12-0943

Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology. / Ridger, Victoria C.; Boulanger, Chantal M.; Angelillo-Scherrer, Anne; Badimon, Lina; Blanc-Brude, Olivier; Bochaton-Piallat, Marie Luce; Boilard, Eric; Búzás, E.; Caporali, Andreas; Dignat-George, Francoise; Evans, Paul C.; Lacroix, Romaric; Lutgens, Esther; Ketelhuth, Daniel F.J.; Nieuwland, Rienk; Toti, Florence; Tuñon, Jose; Weber, Christian; Hoefer, Imo E.; Lip, Gregory Y.H.; Werner, Nikos; Shantsila, Eduard; ten Cate, Hugo; Thomas, Mark; Harrison, Paul.

In: Thrombosis and Haemostasis, Vol. 117, No. 7, 01.01.2017, p. 1296-1316.

Research output: Contribution to journalArticle

Ridger, VC, Boulanger, CM, Angelillo-Scherrer, A, Badimon, L, Blanc-Brude, O, Bochaton-Piallat, ML, Boilard, E, Búzás, E, Caporali, A, Dignat-George, F, Evans, PC, Lacroix, R, Lutgens, E, Ketelhuth, DFJ, Nieuwland, R, Toti, F, Tuñon, J, Weber, C, Hoefer, IE, Lip, GYH, Werner, N, Shantsila, E, ten Cate, H, Thomas, M & Harrison, P 2017, 'Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology', Thrombosis and Haemostasis, vol. 117, no. 7, pp. 1296-1316. https://doi.org/10.1160/TH16-12-0943
Ridger, Victoria C. ; Boulanger, Chantal M. ; Angelillo-Scherrer, Anne ; Badimon, Lina ; Blanc-Brude, Olivier ; Bochaton-Piallat, Marie Luce ; Boilard, Eric ; Búzás, E. ; Caporali, Andreas ; Dignat-George, Francoise ; Evans, Paul C. ; Lacroix, Romaric ; Lutgens, Esther ; Ketelhuth, Daniel F.J. ; Nieuwland, Rienk ; Toti, Florence ; Tuñon, Jose ; Weber, Christian ; Hoefer, Imo E. ; Lip, Gregory Y.H. ; Werner, Nikos ; Shantsila, Eduard ; ten Cate, Hugo ; Thomas, Mark ; Harrison, Paul. / Microvesicles in vascular homeostasis and diseases position paper of the european society of cardiology (ESC) working group on atherosclerosis and vascular biology. In: Thrombosis and Haemostasis. 2017 ; Vol. 117, No. 7. pp. 1296-1316.
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