Microvesicle fractionation using deterministic lateral displacement effect

Andras J. Laki, Lilla Botzheim, Kristof Ivan, Tamas Szabo, Viola Tamasi, Edit Buzas, Pierluigi Civera

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We demonstrate a novel integrated microfluidic device to separate circulating extracellular vesicles from blood stream using the deterministic lateral displacement principle. The device continuously fractionates extracellular vesicles and cells according to size and membrane flexibility by displacing them perpendicularly to the fluid flow direction in a micro-fabricated array of post. Direct separation of different size micro- and nanospheres were demonstrated using a multi-stage separation strategy thus offering a potential route for novel cancer diagnostic approaches where microvesicles can be targeted and intercepted during cell to cell communication.

Original languageEnglish
Title of host publication9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages490-493
Number of pages4
ISBN (Electronic)9781479947270
DOIs
Publication statusPublished - Sep 23 2014
Event9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 - Waikiki Beach, United States
Duration: Apr 13 2014Apr 16 2014

Publication series

Name9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014

Other

Other9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014
CountryUnited States
CityWaikiki Beach
Period4/13/144/16/14

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Laki, A. J., Botzheim, L., Ivan, K., Szabo, T., Tamasi, V., Buzas, E., & Civera, P. (2014). Microvesicle fractionation using deterministic lateral displacement effect. In 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014 (pp. 490-493). [6908856] (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2014.6908856