Microvascular reactivity in lean, overweight, and obese hypertensive adolescents

Péter Monostori, Ákos Baráth, Ildikó Fazekas, Eszter Hódi, Adrienn Máté, Ildikó Farkas, Zsuzsanna Hracskó, I. Varga, Viktória Sümegi, Balázs Gellén, C. Bereczki, S. Túri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The microvascular responses to endothelium-dependent vasodilators (e.g., acetylcholine), endothelium-independent vasodilators (e.g., sodium nitroprusside), and to local heating were studied (for the first time) in adolescents with essential hypertension, grouped according to their body mass index. The forearm microvascular reactivities of thirty-three hypertensive adolescents (ten lean, 13 overweight, and ten obese) and 19 healthy controls were assessed by means of laser Doppler flowmetry. Blood levels of enzymatic and nonenzymatic antioxidants and malondialdehyde were determined. The perfusion increments in response to acetylcholine iontophoresis were not significantly attenuated in the patient groups as compared with the controls. Sodium nitroprusside (SNP) iontophoresis resulted in significantly smaller perfusion increments in the lean and obese hypertensives than in the controls (both p∈

Original languageEnglish
Pages (from-to)1369-1374
Number of pages6
JournalEuropean Journal of Pediatrics
Volume169
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Iontophoresis
Nitroprusside
Acetylcholine
Perfusion
Endothelium-Dependent Relaxing Factors
Laser-Doppler Flowmetry
Malondialdehyde
Vasodilator Agents
Forearm
Heating
Endothelium
Body Mass Index
Antioxidants
Essential Hypertension

Keywords

  • Child
  • Endothelium
  • Juvenile essential hypertension
  • Laser Doppler flowmetry
  • Microvascular dysfunction
  • Oxidative stress

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Microvascular reactivity in lean, overweight, and obese hypertensive adolescents. / Monostori, Péter; Baráth, Ákos; Fazekas, Ildikó; Hódi, Eszter; Máté, Adrienn; Farkas, Ildikó; Hracskó, Zsuzsanna; Varga, I.; Sümegi, Viktória; Gellén, Balázs; Bereczki, C.; Túri, S.

In: European Journal of Pediatrics, Vol. 169, No. 11, 11.2010, p. 1369-1374.

Research output: Contribution to journalArticle

Monostori, P, Baráth, Á, Fazekas, I, Hódi, E, Máté, A, Farkas, I, Hracskó, Z, Varga, I, Sümegi, V, Gellén, B, Bereczki, C & Túri, S 2010, 'Microvascular reactivity in lean, overweight, and obese hypertensive adolescents', European Journal of Pediatrics, vol. 169, no. 11, pp. 1369-1374. https://doi.org/10.1007/s00431-010-1234-3
Monostori P, Baráth Á, Fazekas I, Hódi E, Máté A, Farkas I et al. Microvascular reactivity in lean, overweight, and obese hypertensive adolescents. European Journal of Pediatrics. 2010 Nov;169(11):1369-1374. https://doi.org/10.1007/s00431-010-1234-3
Monostori, Péter ; Baráth, Ákos ; Fazekas, Ildikó ; Hódi, Eszter ; Máté, Adrienn ; Farkas, Ildikó ; Hracskó, Zsuzsanna ; Varga, I. ; Sümegi, Viktória ; Gellén, Balázs ; Bereczki, C. ; Túri, S. / Microvascular reactivity in lean, overweight, and obese hypertensive adolescents. In: European Journal of Pediatrics. 2010 ; Vol. 169, No. 11. pp. 1369-1374.
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