Microtubule's conformational cap

Denis Chrétien, I. Jánosi, Jean Christophe Taveau, Henrik Flyvbjerg

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called 'GTP-cap'. Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.

Original languageEnglish
Pages (from-to)299-303
Number of pages5
JournalCell Structure and Function
Volume24
Issue number5
DOIs
Publication statusPublished - 1999

Fingerprint

Microtubules
Tubulin
Guanosine Triphosphate

Keywords

  • Computer modelling
  • Electron microscopy
  • Microtubule
  • Tubulin

ASJC Scopus subject areas

  • Physiology
  • Structural Biology
  • Cell Biology

Cite this

Chrétien, D., Jánosi, I., Taveau, J. C., & Flyvbjerg, H. (1999). Microtubule's conformational cap. Cell Structure and Function, 24(5), 299-303. https://doi.org/10.1247/csf.24.299

Microtubule's conformational cap. / Chrétien, Denis; Jánosi, I.; Taveau, Jean Christophe; Flyvbjerg, Henrik.

In: Cell Structure and Function, Vol. 24, No. 5, 1999, p. 299-303.

Research output: Contribution to journalArticle

Chrétien, D, Jánosi, I, Taveau, JC & Flyvbjerg, H 1999, 'Microtubule's conformational cap', Cell Structure and Function, vol. 24, no. 5, pp. 299-303. https://doi.org/10.1247/csf.24.299
Chrétien, Denis ; Jánosi, I. ; Taveau, Jean Christophe ; Flyvbjerg, Henrik. / Microtubule's conformational cap. In: Cell Structure and Function. 1999 ; Vol. 24, No. 5. pp. 299-303.
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