Microtubule dissassembly increases the number of opioid receptor binding sites in rat cerebrum membranes

A. Borsodi, G. Toth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The role of microtubules in opioid receptor binding was studied by using microtubule assembly inhibitors. Preincubation of rat cererbum membranes with podophyllotoxin or colchicine provoked a marked increase in the number of binding sites as judged by [3H]-naloxone, [3H]-morphine and [3H]-D-Ala2-Leu5-enkephalin binding experiments. These results indicate microtubule involvement in regulation of opioid receptor expression.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalNeuropeptides
Volume8
Issue number1
DOIs
Publication statusPublished - Jun 1986

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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