Microstructure and dynamic properties of aggrecan assemblies

F. Horkay, Peter J. Basser, Anne Marie Hecht, Erik Geissler

Research output: Contribution to journalArticle

Abstract

The effect of ions on the structure and dynamics of aggracan solutions was investigated using a variety of scattering techniques (neutron spin echo, small angle neutron scattering, static and dynamic light scattering). The results show that aggrecan forms microgel-like assemblies which remain stable in the presence of counter-ions. As opposed to many synthetic polyelectrolytes which exhibit a great sensitivity to ion concentration and charge valency, it was found that aggrecan solutions are remarkable insensitive to charge valence. This property of aggrecan is consistent with its biological role as an ion reservoir mediating calcium metabolism and maintaining dimensional stability in cartilage and bone.

Original languageEnglish
Pages (from-to)1589-1595
Number of pages7
JournalMRS Advances
Volume3
Issue number28
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Aggrecans
dynamic characteristics
assemblies
Ions
microstructure
Microstructure
calcium metabolism
dimensional stability
ions
cartilage
Radiation counters
ion charge
Dimensional stability
Cartilage
Dynamic light scattering
Neutron scattering
ion concentration
Polyelectrolytes
Metabolism
bones

Keywords

  • biomimetic (assembly)
  • neuron scattering
  • self-assembly

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Microstructure and dynamic properties of aggrecan assemblies. / Horkay, F.; Basser, Peter J.; Hecht, Anne Marie; Geissler, Erik.

In: MRS Advances, Vol. 3, No. 28, 01.01.2018, p. 1589-1595.

Research output: Contribution to journalArticle

Horkay, F, Basser, PJ, Hecht, AM & Geissler, E 2018, 'Microstructure and dynamic properties of aggrecan assemblies', MRS Advances, vol. 3, no. 28, pp. 1589-1595. https://doi.org/10.1557/adv.2018.10
Horkay, F. ; Basser, Peter J. ; Hecht, Anne Marie ; Geissler, Erik. / Microstructure and dynamic properties of aggrecan assemblies. In: MRS Advances. 2018 ; Vol. 3, No. 28. pp. 1589-1595.
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