Microspeciation of polypeptides

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A new principle to estimate the concentrations of differently protonated polypeptide species (microspecies) has been elaborated. This method uses a recent type of thermodynamic parameter: group constant, which is a submolecular measure of basicity. The applicability of the principle is discussed, and the relevant relations are deduced. To study the main characteristics of this type of microspeciation, a comparative analysis has been made on glutathione, using either its group constants or its previously published microconstants. The full efficiency of the method is exemplified by the 32 amino acid containing ACTH1-32 microspecies concentrations and their distributions.

Original languageEnglish
Pages (from-to)6345-6349
Number of pages5
JournalJournal of Physical Chemistry
Volume90
Issue number23
Publication statusPublished - 1986

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Polypeptides
polypeptides
Alkalinity
Glutathione
Amino acids
Thermodynamics
Amino Acids
Peptides
glutathione
amino acids
thermodynamics
estimates

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Microspeciation of polypeptides. / Noszál, B.

In: Journal of Physical Chemistry, Vol. 90, No. 23, 1986, p. 6345-6349.

Research output: Contribution to journalArticle

Noszál, B. / Microspeciation of polypeptides. In: Journal of Physical Chemistry. 1986 ; Vol. 90, No. 23. pp. 6345-6349.
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