Microscopic second-order susceptibility tensor analysis

Mikko J. Huttunen, Liisa Naskali, Matti Virkki, Godofredo Bautista, Andras Der, Martti Kauranen

Research output: Contribution to conferencePaper

Abstract

Recent advances in nonlinear microscopy show great potential to study organization and morphology of biological structures [1]. This is especially important for biomedical applications where structural changes can lead to, or be utilized as diagnostic tools of severe diseases [1]. Nonlinear microscopies are in general minimally invasive facilitating in vivo imaging, and can provide deeper penetration than traditional linear microscopy techniques. In addition, coherent nonlinear modalities, such as second-harmonic generation (SHG) microscopy, can provide more quantitative morphological information of the protein conformational order than traditional linear techniques [2,3]. This is due to the intrinsic sensitivity of SHG to symmetry properties of the excited matter, which in conjunction with polarization measurements can be utilized to extract microscopic morphological information [3]. But all the developed quantitative approaches require a varying degree of a priori information, such as knowledge of the overall symmetry or orientation of the material. Neither are they applicable for extracting the complex susceptibility tensor limiting the potential applicability of the techniques [4].

Original languageEnglish
DOIs
Publication statusPublished - Jan 1 2013
Event2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013 - Munich, Germany
Duration: May 12 2013May 16 2013

Other

Other2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013
CountryGermany
CityMunich
Period5/12/135/16/13

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Microscopic second-order susceptibility tensor analysis'. Together they form a unique fingerprint.

  • Cite this

    Huttunen, M. J., Naskali, L., Virkki, M., Bautista, G., Der, A., & Kauranen, M. (2013). Microscopic second-order susceptibility tensor analysis. Paper presented at 2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013, Munich, Germany. https://doi.org/10.1109/CLEOE-IQEC.2013.6801532