MicroRNAs in adrenal tumors: Relevance for pathogenesis, diagnosis, and therapy

P. Igaz, Ivan Igaz, Zoltán Nagy, Gábor Nyíro, Peter M. Szabó, A. Falus, A. Patócs, K. Rácz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Several lines of evidence support the relevance of microRNAs in both adrenocortical and adrenomedullary (pheochromocytomas) tumors. Significantly differentially expressed microRNAs have been described among benign and malignant adrenocortical tumors and different forms of pheochromocytomas that might affect different pathogenic pathways. MicroRNAs can be exploited as markers of malignancy or disease recurrence. Besides tissue microRNAs, novel data show that microRNAs are released in body fluids, and blood-borne microRNAs can be envisaged as minimally invasive markers of malignancy or prognosis. MicroRNAs might even serve as treatment targets that could expand the rather-limited therapeutic repertoire in the field of adrenal tumors. In this review, we present a critical synopsis of the recent observations made in the field of adrenal tumor-associated microRNAs regarding their pathogenic, diagnostic, and potential therapeutic relevance.

Original languageEnglish
Pages (from-to)417-428
Number of pages12
JournalCellular and Molecular Life Sciences
Volume72
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Glandular and Epithelial Neoplasms
MicroRNAs
Pheochromocytoma
Therapeutics
Neoplasms
Body Fluids
Recurrence

Keywords

  • Biomarker
  • Cancer
  • Pathway
  • Treatment

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

MicroRNAs in adrenal tumors : Relevance for pathogenesis, diagnosis, and therapy. / Igaz, P.; Igaz, Ivan; Nagy, Zoltán; Nyíro, Gábor; Szabó, Peter M.; Falus, A.; Patócs, A.; Rácz, K.

In: Cellular and Molecular Life Sciences, Vol. 72, No. 3, 2015, p. 417-428.

Research output: Contribution to journalArticle

Igaz, P. ; Igaz, Ivan ; Nagy, Zoltán ; Nyíro, Gábor ; Szabó, Peter M. ; Falus, A. ; Patócs, A. ; Rácz, K. / MicroRNAs in adrenal tumors : Relevance for pathogenesis, diagnosis, and therapy. In: Cellular and Molecular Life Sciences. 2015 ; Vol. 72, No. 3. pp. 417-428.
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